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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Pain. 2014 Apr 13;155(7):1346–1355. doi: 10.1016/j.pain.2014.04.011

Fig. 4. Neutralization of TNFα, IL-1β, and IL-6, but not CCL2, blocks COMT-dependent pain.

Fig. 4

Administration of α-TNFα (75 μg), α-IL-1β (75 μg), or α-IL-6 (75 μg) prior to OR486 (30 mg/kg) normalized (A, D, G) mechanical allodynia, (B, E, H) mechanical hyperalgesia, and (C, F, I) thermal hyperalgesia. (J-L) Administration of α-CCL2 failed to block OR486-induced increases in mechanical and thermal pain. N=6-8 per group. Data are mean ± SEM. *P<0.05, **P<0.01, ***P<0.001 different from Control IgG/Veh. #P<0.05 different from α-TNFα/Veh and α-TNFα/OR486.