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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Pain. 2014 Apr 13;155(7):1346–1355. doi: 10.1016/j.pain.2014.04.011

Fig. 5. Inhibition of NO synthesis prevents COMT-dependent increases in cytokines.

Fig. 5

Administration of the nitric oxide synthase inhibitor L-NAME (30 mg/kg) prior to OR486 (30 mg/kg) blocked increases in circulating levels of (A) TNFα, (B) IL-1β, (C) IL-6, and (D) CCL2. N=6-10 per group. *P<0.05 different from Veh/Veh.