Figure 1.
DNA methylation of different DNA repetitive elements in normal tissue. DNA methylation of 5 different DNA repetitive elements was measured in ten non-cancerous somatic tissues from four individuals under going post-mortem examinations using bisulfite-PCR Pyrosequencing. Interspersed repeats: (A) LINE1, (B) Alu Yb8; Tandem repeats: (C) Sat-α, (D) NBL-2, (E) D4Z4, (F) inter and intra variation of DNA methylation of different DNA repetitive elements. *p<0.0001. DNA methylation (%) represents the percentage of mCpG/mCpG + CpG + TpG; mC (methylated cytosine), C (unmethylated cytosine) and T (thymine that are generated from CpG by spontaneous evolutionary deamination).