Table 2.
Likelihood (unadjusted and adjusted) of subsequent stillbirth, preeclampsia and small for gestational age neonate by PlGF/sVEGFR-1 and PlGF/sEng Multiples of the Median threshold
| Dependent Variable, Analyte Ratio & MOM Threshold | Others % (n/N) | Outcome % (n/N) | Unadjusted | Adjusted* | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| OR | 95% CI | OR | 95% CI | |||||
|
| ||||||||
| Preeclampsia (n=40) | ||||||||
| PlGF/sVEGFR- 1 <0.3 MOM | 16.2% (199/1229) | 57.5% (23/40) | 7.9 | 4.1 | 15.2 | 6.1 | 3.1 | 11.8 |
|
| ||||||||
| PlGF/sEng <0.3 MoM | 15.9% (196/1229) | 60.0% (24/40) | 5.9 | 1.9 | 18.7 | 7.1 | 3.6 | 13.8 |
|
| ||||||||
| Severe Preeclampsia (n=23) | ||||||||
| PlGF/sVEGFR- 1 <0.3 MOM | 16.5% (205/1246) | 73.9% (17/23) | 11.9 | 2.2 | 66 | 12.2 | .6 | 32 |
|
| ||||||||
| PlGF/sEng <0.3 MoM | 16.3% (202/1246) | 78.3% (18/23) | 11.7 | 2.1 | 64.6 | 16.1 | 5.8 | 44.6 |
|
| ||||||||
| SGA < 10th % (n=108) | ||||||||
| PlGF/sVEGFR- 1 <0.3 MOM | 15.8% (184/1161) | 35.2% (38/108) | 4.2 | 2.4 | 7.3 | 3 | 2 | 4.7 |
|
| ||||||||
| PlGF/sEng <0.3 MoM | 16.3% (189/1161) | 28.7% (31/108) | 3.6 | 2 | 6.4 | 2 | 1.3 | 3.1 |
|
| ||||||||
| SGA < 3rd % (n=23) | ||||||||
| PlGF/sVEGFR- 1 <0.3 MOM | 16.9% (210/1246) | 52.2% (12/23) | 6.9 | 2.4 | 19.4 | 5.5 | 2.3 | 13.1 |
|
| ||||||||
| PlGF/sEng <0.3 MoM | 16.8% (209/1246) | 47.8% (11/23) | 7 | 2.5 | 19.8 | 4.4 | 1.8 | 10.4 |
|
|
||||||||
| Stillbirth (n=5) | ||||||||
| PlGF/sVEGFR- 1 <0.12 MOM | 5.6% (71/1264) | 80% (4/5) | 20.1 | 4.8 | 84.3 | 23.1 | 5.6 | 95.4 |
|
|
||||||||
| PlGF/sEng <0.2 MoM | 10.8% (137/1264) | 60% (3/5) | 8.4 | 2 | 35.1 | 9.1 | 2.2 | 37.2 |
OR=Odds Ratio, CI= Confidence Interval, MoM= Multiples of the Median,
PlGF= placental growth factor, sEng= soluble endoglin, sVEGFR-1=soluble vascular endothelial growth factor receptor-1
ORs represent the likelihood of outcome in subjects with abnormal analyte ratio concentrations (above/below MOM cutoff) relative to patients with normal analyte ratio concentration MoM.
Medians were calculated among uncomplicated pregnancies (n=886) by quantile regression (PlGF/sVEGFR-1 Median= 1.8863 + (−0.0508 *gestational week); PlGF/sEng Median= 354.3280 + (−8.9791*week)), cutoffs were selected based on inspection of receiver operating characteristic curves.
Prediction of stillbirth adjusted for gestational age at venipuncture (continuous);
Prediction of preeclampsia and SGA adjusted for: maternal age (continuous), combined parity & history of preeclampsia, pre-pregnancy body mass index (continuous), tobacco use.
PlGF/sVEGFR-1 MoM cutoff <0.12 (or 5th–6th percentile of uncomplicated pregnancies) for stillbirth, <0.3 (or 17th percentile of uncomplicated pregnancies) for preeclampsia and SGA
PlGF/sEng MoM cutoff <0.2 (or 11th percentile of uncomplicated pregnancies) for stillbirth, <0.3 (or 17th percentile of uncomplicated pregnancies) for preeclampsia and SGA