Table 2. Characteristics of transmission clusters containing Leuven patients with TDR.
| TDR mutations | |||||||||||
| Cluster | Patient ID† | Subtype | Risk of transmission | Country of sampling | Country of origin | Country of infection | Type of infection | Year of diagnosis | NRTI | NNRTI | PI |
| 1 | AY165241 | B | Unknown | Sweden | Unknown | Unknown | Naive - Unknown | 2000* | - | - | - |
| ARCL-1 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2002 | M41LM | - | - | |
| ESAR-1 | B | Heterosexual - Male | Spain | Pakistan | Spain | Naive - Recent | 2003 | - | - | - | |
| FJ481828 | B | MSM | Spain | Unknown | Unknown | Naive - Unknown | 2006* | - | - | - | |
| ESAR-2 | B | MSM | Finland | Russia | Finland | Naive - Chronic | 2007 | - | - | - | |
| 2 | EU248399 | B | Unknown | Belgium | Unknown | Unknown | Naive - Unknown | 2003* | - | K103N | - |
| JN101707 | B | Unknown | United Kingdom | Unknown | Unknown | Unknown | 2004* | - | K103N | - | |
| ARCL-2 | B | Heterosexual - Male | Belgium | Belgium | Belgium | Naive - Chronic | 2007 | - | K103N | - | |
| ARCL-3 | B | Bisexual - Male | Belgium | Belgium | Unknown | Naive - Chronic | 2009 | - | K103N | - | |
| JF683797 | B | Unknown | Cyprus | Unknown | Unknown | Naive - Unknown | 2009* | - | K103N | - | |
| 3 | ARCL-4 | B | MSM | Belgium | Belgium | Belgium | Naive -Recent § | 2001 | L210W, T215S | - | I54V, N88D |
| EU248438 | B | Unknown | Belgium | Unknown | Unknown | Naive - Unknown | 2003* | L210W, T215S | - | I54V, N88D | |
| ARCL-5 | B | MSM | Belgium | Belgium | Belgium | Naive - Recent | 2005 | L210W, T215S | - | I54V, N88D | |
| ARCL-6 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic § | 2007 | L210W, T215S | - | I54V, N88D | |
| ARCL-7 | B | MSM | Belgium | Italy | Belgium | Naive - Recent | 2010 | L210W,T215S | - | I54V,N88D | |
| ARCL-8 | B | MSM | Belgium | Belgium | Unknown | Naive - Recent | 2011 | L210W, T215S | - | I54V, N88D | |
| 4 | DQ177230 | B | Unknown | Belgium | Unknown | Unknown | Naive - Unknown | 2002* | T215E | - | - |
| ARCL-9 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2005 | T215E | - | - | |
| 5 | ARCL-10 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic § | 2007 | T215D | - | - |
| ARCL-11 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2007 | T215D | - | - | |
| ARCL-12 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2007 | T215D | - | - | |
| ARCL-13 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2007 | T215D | - | - | |
| ARCL-14 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2010 | - | - | - | |
| ARCL-15 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2010 | - | - | - | |
| ARCL-16 | B | MSM | Belgium | Belgium | Unknown | Naive - Recent | 2011 | T215D | - | - | |
| ARCL-17 | B | MSM | Belgium | Belgium | Unknown | Naive - Recent | 2011 | T215D | - | - | |
| ARCL-18 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2012 | T215D | - | - | |
| 6 | DQ206665 | B | Unknown | Argentina | Unknown | Unknown | Naive - Unknown | 2004* | - | K103N, P225H | - |
| JN670104 | B | Unknown | Argentina | Unknown | Unknown | Treated | 2005* | M41L, M184V, T215Y | - | D30N, N88D | |
| ARCL-19 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2007 | T215S | K103N | - | |
| ARCL-20 | B | MSM | Belgium | Belgium | Belgium | Naive - Recent | 2007 | - | K103N | - | |
| 7 | ARCL-21 | B | MSM | Belgium | Belgium | Belgium | Naive - Recent | 2009 | - | - | M46L |
| ARCL-22 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 2010 | K219Q | - | - | |
| JQ650683 | B | MSM | Netherlands | Unknown | Unknown | Unknown | Unknown | - | - | M46L | |
| 8 | ARCL-23 | B | MSM | Belgium | Belgium | Unknown | Naive - Recent | 2011 | T215E | - | - |
| JQ650714 | B | MSM | Netherlands | Unknown | Unknown | Unknown | Unknown | T215E | - | - | |
| 9 | ARCL-24 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2006 | - | - | - |
| ARCL-25 | B | Transfusion - Male | Belgium | Belgium | Unknown | Naive - Chronic | 2010 | K219RK | - | - | |
| 10 | ARCL-26 | B | MSM | Belgium | Indonesia | Asia | Naive - Chronic | 2001 | T215D | - | - |
| ARCL-27 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2003 | T215D | - | - | |
| 11 | ARCL-28 | B | MSM | Belgium | Belgium | Unknown | Naive - Chronic | 1998 | T215C | - | - |
| ARCL-29 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2002 | T215S | - | - | |
| 12 | ARCL-30 | B | MSM | Belgium | Belgium | Belgium | Naive - Recent | 2003 | - | - | - |
| ARCL-31 | B | Bisexual - Male | Belgium | Belgium | Belgium | Naive - Recent | 2009 | K219R | - | - | |
| ARCL-32 | B | Bisexual - Male | Belgium | Belgium | Unknown | Naive - Chronic | 2009 | - | - | - | |
| ARCL-33 | B | Unknown | Belgium | Belgium | Belgium | Naive - Chronic | 2010 | - | - | - | |
| 13 | EU817049 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 1998* | K219Q | - | - |
| EU817059 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2001* | K219Q | - | - | |
| EU817062 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2001* | K219R | - | - | |
| ARCL-34 | B | MSM | Belgium | Belgium | Belgium | Naive - Chronic | 2007 | K219Q | - | - | |
| ARCL-35 | B | MSM | Belgium | Belgium | Belgium | Naive - Recent | 2006 | K219Q | - | - | |
| ESAR-1 | B | MSM/bisexual | Italy | Italy | Unknown | Naive - Chronic | 2003 | K219Q | - | - | |
| EU817050 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2003* | K219Q | - | - | |
| EU817048 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2004* | K219R | - | - | |
| EU817061 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2004* | K219Q | - | - | |
| DQ345509 | B | Unknown | Argentina | Unknown | Unknown | Naive - Recent | 2005* | - | - | - | |
| EU817058 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817060 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817065 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817056 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817051 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817068 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817047 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817055 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| EU817063 | B | Unknown | United Kingdom | Unknown | Unknown | Naive - Unknown | 2005* | K219QR | - | - | |
| FJ469703 | B | Unknown | United States | Unknown | Unknown | Naive - Unknown | 2005* | K219Q | - | - | |
| ESAR-2 | B | MSM/bisexual | Germany | Germany | Unknown | Naive - Recent | 2006 | K219Q | - | - | |
| ESAR-3 | B | MSM/bisexual | Cyprus | Cyprus | Unknown | Naive - Chronic | 2007 | - | - | - | |
| ESAR-4 | B | MSM/bisexual | Germany | Germany | Germany | Naive - Recent | 2007 | - | - | - | |
| JF683765 | B | Unknown | Cyprus | Unknown | Unknown | Naive - Unknown | 2007* | - | - | - | |
| JF683791 | B | Unknown | Cyprus | Unknown | Unknown | Naive - Unknown | 2009* | - | - | - | |
| JF683808 | B | Unknown | Cyprus | Unknown | Unknown | Naive - Unknown | 2009* | - | - | - | |
| 14 | ARCL-36 | C | Heterosexual - Female | Belgium | Belgium | Unknown | Naive - Chronic | 2012 | - | - | M46LM |
| ARCL-37 | C | Heterosexual - Male | Belgium | Ethiopia | Unknown | Naive - Chronic | 2012 | - | - | - | |
| 15 | ARCL-38 | CRF01_AE | Heterosexual - Female | Belgium | Thailand | Thailand | Naive - Chronic | 2005 | - | - | - |
| ARCL-39 | CRF01_AE | Heterosexual - Male | Belgium | Belgium | Belgium | Naive - Chronic | 2005 | - | - | M46IM | |
| 16 | JX290261 | CRF02_AG | Unknown | Russia | Unknown | Unknown | Unknown | 2001 or 2002‡ | - | - | - |
| AY829204 | CRF02_AG | IVDU - Male | Uzbekistan | Unknown | Unknown | Unknown | 2002* | - | - | - | |
| AY829207 | CRF02_AG | IVDU - Male | Uzbekistan | Unknown | Unknown | Unknown | 2002* | - | - | - | |
| AY829214 | CRF02_AG | IVDU - Male | Uzbekistan | Unknown | Unknown | Unknown | 2002* | - | - | - | |
| HQ449394 | CRF02_AG | Unknown - Female | Russia | Unknown | Unknown | Unknown | 2005‡ | - | - | - | |
| DQ465230 | CRF02_AG | MTCT | USA | Unknown | Unknown | Unknown | 2006* | - | - | - | |
| GQ290726 | CRF02_AG | Unknown | South Korea | Unknown | Unknown | Naive - Unknown | 2008* | - | - | - | |
| GQ290743 | CRF02_AG | Unknown | South Korea | Unknown | Unknown | Naive - Unknown | 2008* | - | - | - | |
| HQ412530 | CRF02_AG | Unknown - Male | Russia | Unknown | Unknown | Unknown | 2008* | L74I, M184V, K219E | L100I, K101E, Y181C, G190S | - | |
| HQ115069 | CRF02_AG | Unknown - Male | Ukraine | Unknown | Unknown | Unknown | 2009‡ | - | - | - | |
| JX500703 | CRF02_AG | Unknown | Russia | Unknown | Unknown | Unknown | 2010* | - | - | - | |
| ARCL-40 | CRF02_AG | Heterosexual - Female | Belgium | Kazakhstan | Unknown | Naive - Chronic | 2011 | K219RK | - | - | |
| JX500697 | CRF02_AG | Unknown | Russia | Unknown | Unknown | Unknown | 2011* | - | - | - | |
| JX500706 | CRF02_AG | Unknown | Russia | Unknown | Unknown | Unknown | 2011* | - | - | - | |
| KC509858 | CRF02_AG | Unknown - Female | Russia | Unknown | Unknown | Unknown | 2012* | - | - | - | |
| KC120872 | CRF02_AG | Unknown | South Korea | Unknown | Unknown | Unknown | Unknown | - | - | - | |
| KC120881 | CRF02_AG | Unknown | South Korea | Unknown | Unknown | Unknown | Unknown | - | - | - | |
Abbreviations: ARCL: AIDS Reference Center Leuven, CRF: Circulating recombinant form, ESAR: European Society for Translational Antiviral Research, IVDU: intravenous drug user, NRTI: nucleoside reverse transcriptase inhibitors, NNRTI: non-nucleoside reverse transcriptase inhibitors, MSM: men who have sex with men, MTCT: mother to child transmission, PI: protease inhibitors,†Patient ID includes patients of the Leuven cohort (bold and italics), ESAR controls and accession numbers of NCBI database *Control sequences have available year of sampling. ‡Control sequences with year of diagnosis available. §Sequences were also included when the patient was on antiretroviral treatment.