Table 1. Pyrvinium treated CRC cell lines: summary.
CRC Cells | MTT Assay IC50 (nM) | Clonogenic Assay IC50 (nM) | P53 Mutations | Oncogenes Expressed |
HT29 | 135 | 10 | G>A (Arg->His) 273 | MYC, RAS, MYB, FOS |
SW480 | 47 | 13 | G>A (Arg->His) 273/C>T (Pro->Ser) 309 | MYC, RAS, MYB, FOS |
SW620 | 513 | 54 | G>A (Arg->His) 273 | MYC, RAS, MYB, FOS |
HCT116 | 87 | 8 | WT p53, p21 deficient | MYC, RAS, MYB |