Table 4. Multivariable Cox regression models for renal outcome of decline in eGFR>50%.
| Model 1 | Model 2 | Model 3 | ||||
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (1 year) | 0.97 (0.95 to 1.00) | 0.030 | 0.98 (0.95 to 1.01) | 0.90 | 0.98 (0.95 to 1.03) | 0.083 |
| eGFR (1 ml/min/1.73 m2) | 0.97 (0.96 to 0.98) | <0.001 | 0.98 (0.97 to 0.99) | <0.001 | 0.98 (0.97 to 0.99) | <0.001 |
| TA_MAP (1 mmHg) | 1.03 (0.98 to 1.08) | 0.22 | 1.04 (0.99 to 1.09) | 0.13 | 1.04 (0.99 to 1.09) | 0.17 |
| Hypertension (vs. no) | 1.23 (0.69 to 2.20) | 0.48 | 0.95 (0.52 to 1.78) | 0.88 | 0.97 (0.52 to 1.80) | 0.97 |
| TA-P (g/g) | ||||||
| <0.3 | reference | reference | reference | |||
| 0.3 to 0.99 | 3.45 (0.41 to 28.80) | 0.25 | 2.93 (0.35 to 24.98) | 0.33 | 2.82 (0.32 to 24.72) | 0.35 |
| 1.0 to 2.99 | 47.28 (6.38 to 350.15) | <0.001 | 26.59 (3.48 to 203.34) | 0.002 | 25.0 (3.17 to 197.0) | 0.002 |
| ≥3.0 | 406.35 (49.30 to 3349.18) | <0.001 | 288.86 (34.03 to 2451.86) | <0.001 | 244.07 (27.09 to 2198.88) | <0.001 |
| Pathologic findings | ||||||
| M1 (vs. M0) | - | - | 1.30 (0.64 to 2.66) | 0.47 | 1.33 (0.65 to 2.75) | 0.44 |
| E1 (vs. E0) | - | - | 0.97 (0.43 to 2.17) | 0.94 | 0.94 (0.42 to 2.11) | 0.87 |
| S1 (vs. S0) | - | - | 1.05 (0.59 to 1.88) | 0.86 | 1.01 (0.56 to 1.82) | 0.97 |
| T1 (vs. T0) | - | - | 2.78 (1.29 to 5.99) | 0.009 | 2.81 (1.29 to 6.11) | 0.009 |
| T2 (vs. T0) | - | - | 4.27 (1.80 to 10.17) | 0.001 | 4.35 (1.81 to 10.42) | 0.001 |
| Treatment | ||||||
| RAS blockers (vs. no) | - | - | - | - | 1.11 (0.30 to 4.06) | 0.88 |
| Corticosteroids (vs. no) | - | - | - | - | 1.37 (0.65 to 2.88) | 0.41 |
Abbreviations: HR, hazard ratio; eGFR, estimated glomerular filtration rate; TA-MAP, time-averaged mean arterial pressure; TA-P, time-averaged proteinuria; RAS, renin-angiotensin system.