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. 2014 Jul 8;9(7):e101949. doi: 10.1371/journal.pone.0101949

Table 1. Sociodemographic and clinical characteristics of HIV-infected individuals.

Rapid progressors Classic progressors Viremic slow progressors Aviremic slow progressors P
Characteristics (n = 13) (n = 17) (n = 7) (n = 6)
Age at first visit (years) 34±7 38±8 46±9 44±9 0.005a
Sex (male/female) 12/1 17/0 7/0 3/3 0.005
Race (white/other) 12/1 16/1 6/1 5/1 NS
CD4+ T cells/mm3
Acute phase 533±140 781±213 na na 0.002
Early phase 446±40 714±46 na na 0.0008
Chronic phase 443±193 629±244 562±122 888±122 0.011b
Nadir 254±118 432±140 506±129 506±175 0.0005c
Viremia, ×103 copies/ml d
Acute phase 366±705 76±126 na na NS
Early phase 121±186 71±190 na na NS
Chronic phase 7.65±15.3 37.7±62.3 3.01±1.86 <0.05d 0.003e
Peak 570±808 202±236 8.5±6.5 0.065±0.027 0.0001f

Age, CD4 and viremia are expressed as mean ±SD. Sex and race were compared using Fisher exact test. Pairwise comparisons of CD4 and viremia for early phases were performed using unpaired Student's t tests. Comparisons among all groups (age at first visit, CD4, viremia in the chronic phase, nadir CD4) were performed with the one-way analysis of variance test. n, numbers; NS, not significant; na, not available.

a

P = 0.004 and 0.050 for the comparison of age between rapid and viremic slow progressors, and classic and viremic slow progressors, respectively, as determined by the Mann-Whitney test.

b

P = 0.008 for the comparison of CD4+ T cells/mm3 in chronic phase between rapid progressors and aviremic slow progressors, as determined by the Mann-Whitney test.

c

P = 0.0008 and 0.001 and 0.020 nadir CD4 for the comparison between rapid and classic progressors, rapid and viremic slow progressors, and rapid and aviremic slow progressors, respectively, as determined by the Mann-Whitney test.

d

Fifty copies/ml corresponds to the detection threshold of the viral load test.

e

P = 0.002 and 0.002 for the comparison of viremia in chronic phase between classic progressors and aviremic slow progressors, and viremic and aviremic slow progressors, respectively, as determined by the Mann-Whitney test.

f

P = 0.006, 0.0007, 0.0005, 0.0004 and 0.001 for the comparison of peak viremia between rapid progressors and viremic slow progressors, rapid progressors and aviremic slow progressors, classic progressors and viremic slow progressors, classic progressors and aviremic slow progressors, and viremic and aviremic slow progressors, respectively, as determined by the Mann-Whitney test.