Table 2. Summary of meta-analysis of association of E-selectin gene polymorphisms and EH risk.
| SNP | Total orsubgroupanalysis | Studies(Cases/Controls) | Allelic model | Dominant model | Recessive model | ||||||
| OR (95%CI) | P OR | P forheterogeneity | OR (95%CI) | P OR | P forheterogeneity | OR (95%CI) | P OR | P forheterogeneity | |||
| A561C | Total | 12 (2813/2817) | 2.359 (1.981–2.808) | 0.001 | 0.176 | 2.280 (1.893–2.748) | <0.001 | 0.123 | 5.284 (2.679–10.420) | <0.001 | 0.520 |
| Ethnicity | |||||||||||
| Han | 6 (1579/1536) | 2.557 (1.939–3.373) | <0.001 | 0.138 | 2.365 (1.758–3.181) | <0.001 | 0.393 | 4.684 (2.008–10.932) | <0.001 | 0.390 | |
| Others | 6 (1234/1281) | 2.230 (1.781–2.792) | <0.001 | 0.260 | 2.224 (1.750–2.828) | <0.001 | 0.046 | 6.468 (2.067–20.244) | 0.001 | 0.401 | |
| Total sample size | |||||||||||
| Less than 600 | 8 (1301/1359) | 2.175 (1.743–2.714) | <0.001 | 0.204 | 2.307 (1.824–2.919) | <0.001 | 0.077 | 2.480 (0.815–7.546) | 0.110 | 1.000 | |
| More than 600 | 4 (1512/1458) | 2.672 (2.011–3.549) | <0.001 | 0.221 | 2.237 (1.648–3.037) | <0.001 | 0.299 | 7.450 (3.067–18.095) | <0.001 | 0.101 | |
| Genotyping methods | |||||||||||
| PCR-RFLP | 8 (1384/1399) | 2.299 (1.837–2.877) | <0.001 | 0.340 | 2.477 (1.743–3.156) | <0.001 | 0.175 | 2.227 (0.962–5.158) | 0.062 | 1.000 | |
| Taqman-PCR | 4 (1429/1418) | 2.450 (1.857–3.233) | <0.001 | 0.065 | 2.025 (1.513–2.711) | <0.001 | 0.171 | 17.609 (4.225–73.385) | <0.001 | 0.702 | |
| C1839T | Total | 6 (1700/1682) | 0.805 (0.649–0.999) | 0.049 | 0.569 | 0.785 (0.627–0.983) | 0.035 | 0.506 | 1.250 (0.336–4.652) | 0.739 | 0.587 |
| Ethnicity | |||||||||||
| Han | 2 (858/844) | 0.848 (0.612–1.173) | 0.319 | 0.856 | 0.835 (0.595–1.173) | 0.299 | 0.696 | 0.992 (0.226–4.364) | 0.992 | 0.400 | |
| Others | 4 (842/838) | 0.774 (0.580–1.032) | 0.081 | 0.300 | 0.748 (0.553–1.010) | 0.058 | 0.270 | 3.102 (0.126–76.499) | 0.489 | - | |
| Total sample size | |||||||||||
| Less than 600 | 3 (535/539) | 0.847 (0.605–1.187) | 0.336 | 0.265 | 0.819 (0.575–1.168) | 0.270 | 0.219 | 3.102 (0.126–76.499) | 0.489 | - | |
| More than 600 | 3 (1165/1143) | 0.778 (0.587–1.029) | 0.079 | 0.588 | 0.763 (0.570–1.020) | 0.068 | 0.553 | 0.992 (0.226–4.364) | 0.992 | 0.400 | |
| Genotyping methods | |||||||||||
| PCR-RFLP | 2 (271/267) | 0.928 (0.602–1.430) | 0.734 | 0.134 | 0.919 (0.581–1.454) | 0.719 | 0.117 | - | - | - | |
| Taqman-PCR | 4 (1429/1415) | 0.769 (0.599–0.986) | 0.038 | 0.778 | 0.747 (0.577–0.967) | 0.027 | 0.734 | 1.250 (0.336–4.652) | 0.739 | 0.587 | |