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. 2014 Jul 8;9(7):e101871. doi: 10.1371/journal.pone.0101871

Figure 5. Inhibition of CaMKII with KN-93 affects the spontaneous frequency of the heart.

Figure 5

A. Flies of 7 days treated with 5 µM KN-93 did not exhibit changes of fluorescence intensity (top, left graph), +dF/dtmax, −dF/dtmax (top, right graph), FDHM (bottom, left graph), TTP (bottom, middle graph) neither t1/2 (bottom, right graph) compared whit the same 7 days flies previously observed without incubated with the CaMKII inhibitor. B. Inhibition of CaMKII reduced spontaneous heart rate without changes of the arrhythmicity index. Mean ± SEM of 24 flies. *p≤0.05.