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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Stat Med. 2012 Jul 5;31(28):3748–3759. doi: 10.1002/sim.5446

Table 1.

Empirical characteristics of β̂1 in 1000 simulations with n = 100 in the Assay-comparison study and n1 = n2 = 250 in the Main case-control study for models regressing D on the underlying X (True), the normalized (RC) and the raw error-prone W (Naïve).

τ12
τ22
δ2 eβ1 Bias MSE Coverage
True RC Naïve True RC Naïve True RC Naïve
0.1 0.1 0 2.0 0.02 0.01 −0.05 0.03 0.03 0.03 0.96 0.96 0.94
0.5 0.02 −0.01 −0.15 0.03 0.03 0.04 0.96 0.96 0.81
1.0 0.02 −0.02 −0.24 0.03 0.04 0.07 0.96 0.96 0.56
0.5 0.5 0.02 −0.02 −0.22 0.03 0.04 0.07 0.96 0.96 0.62
1.0 0.02 −0.03 −0.29 0.03 0.04 0.10 0.96 0.95 0.35
1.0 1.0 0.02 −0.05 −0.34 0.03 0.05 0.13 0.96 0.94 0.19
0.1 0.1 5.0 0.05 0.00 −0.10 0.06 0.06 0.06 0.96 0.96 0.90
0.5 0.05 −0.08 −0.34 0.06 0.06 0.15 0.96 0.93 0.54
1.0 0.05 −0.14 −0.54 0.06 0.08 0.32 0.96 0.88 0.16
0.5 0.5 0.05 −0.15 −0.51 0.06 0.08 0.29 0.96 0.87 0.20
1.0 0.05 −0.21 −0.67 0.06 0.10 0.47 0.96 0.81 0.04
1.0 1.0 0.05 −0.26 −0.79 0.06 0.13 0.64 0.96 0.74 0.00
0.1 0.1 0.5 2.0 0.02 0.01 −0.08 0.03 0.03 0.03 0.96 0.96 0.92
0.5 0.02 −0.01 −0.18 0.03 0.03 0.05 0.96 0.96 0.74
1.0 0.02 −0.02 −0.26 0.03 0.04 0.09 0.96 0.96 0.45
0.5 0.5 0.02 −0.02 −0.24 0.03 0.04 0.08 0.96 0.96 0.54
1.0 0.02 −0.03 −0.31 0.03 0.04 0.11 0.96 0.95 0.28
1.0 1.0 0.02 −0.05 −0.35 0.03 0.05 0.14 0.96 0.94 0.16
0.1 0.1 5.0 0.05 0.00 −0.19 0.06 0.06 0.08 0.96 0.96 0.82
0.5 0.05 −0.08 −0.42 0.06 0.06 0.21 0.96 0.93 0.35
1.0 0.05 −0.14 −0.62 0.06 0.08 0.41 0.96 0.88 0.06
0.5 0.5 0.05 −0.15 −0.56 0.06 0.08 0.34 0.96 0.87 0.13
1.0 0.05 −0.21 −0.72 0.06 0.10 0.54 0.96 0.81 0.02
1.0 1.0 0.05 −0.26 −0.81 0.06 0.13 0.68 0.96 0.74 0.00
0.1 0.1 1.0 2.0 0.02 0.01 −0.17 0.03 0.03 0.05 0.96 0.96 0.79
0.5 0.02 −0.01 −0.25 0.03 0.03 0.08 0.96 0.96 0.51
1.0 0.02 −0.02 −0.32 0.03 0.04 0.11 0.96 0.96 0.24
0.5 0.5 0.02 −0.02 −0.29 0.03 0.04 0.10 0.96 0.96 0.34
1.0 0.02 −0.03 −0.35 0.03 0.04 0.13 0.96 0.95 0.16
1.0 1.0 0.02 −0.05 −0.38 0.03 0.05 0.16 0.96 0.94 0.08
0.1 0.1 5.0 0.05 0.00 −0.39 0.06 0.06 0.18 0.96 0.96 0.42
0.5 0.05 −0.08 −0.59 0.06 0.06 0.37 0.96 0.93 0.08
1.0 0.05 −0.14 −0.75 0.06 0.08 0.58 0.96 0.88 0.01
0.5 0.5 0.05 −0.15 −0.67 0.06 0.08 0.47 0.96 0.87 0.03
1.0 0.05 −0.21 −0.81 0.06 0.10 0.68 0.96 0.81 0.00
1.0 1.0 0.05 −0.26 −0.88 0.06 0.13 0.79 0.96 0.74 0.00

Note: τ12 and τ22 are the measurement error variances from Lab 1 and Lab 2, respectively; δ2 is the mean of the measurement error from Lab 2, and Lab 1 is regarded as the reference(i.e., δ1 = 0); eβ1 is the odds ratio of one increment increase of X from the underlying logistic regression model.