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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neurobiol Aging. 2014 Apr 18;35(10):2419.e17–2419.e21. doi: 10.1016/j.neurobiolaging.2014.04.009

Figure 2.

Figure 2

Repeat-primed PCR analysis of genomic DNA from the brain tissue of a C9ORF72 mutation carrier demonstrates the characteristic saw tooth pattern associated with the GGGGCC hexanucleotide repeat expansion (A), which the control sample does not show (B). Immunohistochemical staining of the hippocampus CA1 region of a carrier (C) with polyclonal antibody 3154 (GP), which recognizes the GP repeat motif that is expressed in both the sense and the antisense directions. Multiple pyramidal neurons display cytoplasmic inclusions containing RAN proteins, with no similar staining seen in controls (D).