Table 1.
Demographic and baseline characteristics of the out-of-hospital cardiac arrest patients treated with hypothermia, stratified by duration of downtime
| All patients (n=86) |
≤ 10 min (n=24) |
11 - 20 min (n=27) |
21 - 30 min (n=12) |
> 30 min (n=23) |
p- valu e |
|
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, years | 64.5(52.8-76.0) | 69.5(54.5-77.5) | 66.0(54.0-75.0) | 69.0(46.0-81.8) | 57.0(44.0-72.0) | 0.40 |
| Male | 57(66.3) | 12(50.0) | 20(74.1) | 8(66.7) | 17(73.9) | 0.24 |
| Race (white) | 69(80.2) | 18(75.0) | 22(81.5) | 9(75.0) | 20(87.0) | 0.51 |
| Transfer – other hospital | 38 (45.8) | 9 (37.5) | 8 (33.3) | 8 (66.7) | 13 (56.5) | 0.15 |
| Co-morbidities | ||||||
| Hypertension | 41(47.7) | 13(54.2) | 15(55.6) | 6(50.0) | 7(30.4) | 0.28 |
| Diabetes mellitus | 21(24.4) | 7(29.2) | 9(33.3) | 3(25.0) | 2(8.7) | 0.21 |
| Coronary artery disease |
21(24.4) | 7(29.2) | 10(37.0) | 1(8.3) | 3(13.0) | 0.12 |
| Cancer | 3( 3.5) | 1(4.2) | 2(7.4) | 0(0.0) | 0(0.0) | 0.47 |
| No co-morbidities | 16(18.6) | 4(16.7) | 4(14.8) | 0(0.0) | 8(34.8) | 0.07 |
| Arrest characteristics | ||||||
| Location | 0.65 | |||||
| Private/home | 36(41.9) | 7(29.2) | 12(44.4) | 5(41.7) | 12(52.2) | |
| Public space | 29(33.7) | 8(33.3) | 12(44.4) | 3(25.0) | 6(26.1) | |
| Others or unknown | 21(24.4) | 9(37.5) | 3(11.1) | 4(33.3) | 5(21.7) | |
| Witnessed | 61(70.9) | 21(87.5) | 19(70.4) | 8(72.7) | 13(56.5) | 0.13 |
| Bystander CPR | 60(69.8) | 19(79.2) | 20(74.1) | 6(50.0) | 15(68.2) | 0.32 |
| First arrest rhythm | 0.51 | |||||
| Shockable | 44(51.2) | 11(45.8) | 17(63.0) | 6(50.0) | 10(43.5) | |
| Non-shockable | 42(48.8) | 13(54.2) | 10(37.0) | 6(50.0) | 13(56.5) | |
| Low-flow time, min | 15.0(8.0-28.8) | 6.0(5.0-8.0) | 13.5(10.0-15.0) | 23.0(17.0-25.0) | 40.0(35.0-62.0) | <0.0 1 |
| Downtime, min | 18.5(10.-32.3) | 7.0(5.0-10.0) | 15.0(13.0-20.0) | 25.0(24.3-27.8) | 45.0(40.0-65.0) | <0.0 1 |
| Initial vital signs | ||||||
| Systolic BP, mmHg | 117.5±31.6 | 128.2±35.3 | 116.2±29.4 | 105.5±35.6 | 115.5±27.0 | 0.23 |
| Diastolic BP, mmHg | 69.7±22.8 | 81.9±24.4 | 63.6±18.7 | 56.8±13.4 | 70.4±24.0 | 0.10 |
| Heart rate,/ minute | 96.2±26.2 | 90.5±26.8 | 104.7±30.3 | 92.1±22.1 | 94.3±21.7 | 0.24 |
|
Initial laboratory
values |
||||||
| Lactate, mmol/L | 6.6±3.4 | 4.8±2.2 | 7.0±3.7 | 8.2±4.1 | 7.1±3.1 | 0.06 |
| Glucose, mg/dL | 238.4±116.5 | 226.5±151.0 | 255.2±114.3 | 175.9±51.8 | 253.0±92.0 | 0.40 |
| APACHEII score (24 hr) |
25.5±6.3 | 25.0±5.9 | 26.1±7.9 | 23.0±5.0 | 26.8±5.5 | 0.43 |
Values are expressed as mean ± SD or median with interquartile range and n (%). CPR, cardiopulmonary resuscitation; BP, blood pressure; WBC, White blood cell count; APACHE II, acute physiology and chronic health evaluation II