Table 5.
Comparison of the distribution of MCP1 rs1024611 polymorphic variants in HBsAg positive/anti-HBs negative HD patients and anti-HBc positive/HBsAg negative/anti-HBs positive HD without or with DM.
| Genotype | HD patients HBsAg positive/anti-HBs negative (frequency) | HD patients anti-HBc positive/ HBsAg negative/ anti-HBs positive HD (frequency) | Odds ratio (95%CI) | Two-tailed P | Ptrend | Pgenotyping | Power (%) |
|---|---|---|---|---|---|---|---|
| All HD patients | |||||||
| n=15 | n=126 | ||||||
| AA | 4 (0.27) | 66 (0.52) | Referent | – | 0.021 | 0.064 | |
| AG | 7 (0.47) | 48 (0.38) | 0.416 (0.085–1.756) | 0.292 | 20.2 | ||
| GG | 4 (0.27) | 12 (0.10) | 0.182 (0.030–1.147) | 0.073 | 56.3 | ||
| AG+GG | 11 (0.73) | 60 (0.48) | 0.331 (0.073–1.201) | 0.105 | 38.4 | ||
| MAF | 15 (0.50) | 72 (0.29) | 0.400 (0.173–0.932) | 0.033 | 61.4 | ||
| HD cases without DM | |||||||
| n=10 | n=89 | ||||||
| AA | 3 (0.3) | 49 (0.55) | Referent | – | 0.043 | 0.096 | |
| AG | 4 (0.4) | 32 (0.36) | 0.490 (0.068–3.130) | 0.602 | 11.9 | ||
| GG | 3 (0.3) | 8 (0.09) | 0.163 (0.019–1.494) | 0.121 | 47.9 | ||
| AG+GG | 7 (0.7) | 40 (0.45) | 0.350 (0.055–1.672) | 0.242 | 28.9 | ||
| MAF | 10 (0.5) | 48 (0.27) | 0.369 (0.130–1.062) | 0.066 | 51.2 | ||
| HD cases with DM | |||||||
| n=5 | n=37 | ||||||
| AA | 1 (0.2) | 17 (0.46) | Referent | – | 0.273 | 0.528 | |
| AG | 3 (0.6) | 16 (0.43) | 0.314 (0.006–4.509) | 0.646 | 10.1 | ||
| GG | 1 (0.2) | 4 (0.11) | 0.235 (0.003–23.05) | 0.791 | 10.4 | ||
| AG+GG | 4 (0.8) | 20 (0.54) | 0.294 (0.006–3.444) | 0.550 | 6.9 | ||
| MAF | 5 (0.5) | 24 (0.32) | 0.480 (0.101–2.323) | 0.451 | 15.9 | ||
anti-HBc – antibodies to core antigen of hepatitis B virus; anti-HBs – antibodies to surface antigen of hepatitis B virus; DM – diabetes mellitus, hemodialysis; HBsAg – surface antigen of hepatitis B virus; HD – hemodialysis; MAF – minor allele frequency.
Significant differences are indicated using bold font.