Table 6.
Comparison of MCP1 rs1024611 genotype frequencies between hepatitis B virus carriers [AA 4 (0.27), AG 7 (0.47), GG 4 (0.27), MAF (0.50)] and other selected groups.
| Description of HD group | rs1024611 | rs1024611 genotype frequencies | Odds ratio (95%CI) | Two-tailed P | Ptrend | Pgenotyping | Power (%) |
|---|---|---|---|---|---|---|---|
| Controls (n=437) | AA | 225 (0.51) | 2.919 (0.846–12.73) | 0.101 | 0.010 | 0.021 | 42.0 |
| AG | 177 (0.41) | 0.778 (0.242–2.571) | 0.822 | 5.3 | |||
| GG | 35 (0.08) | 0.239 (0.067–1.091) | 0.065 | 56.8 | |||
| AG+GG | 212 (0.49) | 0.343 (0.079–1.181) | 0.101 | 41.9 | |||
| MAF | 247 (0.28) | 0.394 (0.177–0.880) | 0.022 | 67.7 | |||
| HD anti-HBc negative patients (n=754) | AA | 349 (0.46) | 2.370 (0.694–10.29) | 0.209 | 0.015 | 0.012 | 26.9 |
| AG | 352 (0.47) | 1.001 (0.314–3.277) | 1.000 | 3.6 | |||
| GG | 53 (0.07) | 0.208 (0.059–0.929) | 0.040 | 61.4 | |||
| AG+GG | 405 (0.54) | 0.422 (0.097–1.442) | 0.209 | 26.9 | |||
| MAF | 458 (0.30) | 0.436 (0.197–0.967) | 0.041 | 59.5 | |||
| HD patients with isolated anti-HBc positivity (n=28) | AA | 16 (0.57) | 3.667 (0.797–19.27) | 0.110 | 0.014 | 0.038 | 39.0 |
| AG | 11 (0.39) | 0.740 (0.175–3.184) | 0.882 | 5.0 | |||
| GG | 1 (0.04) | 0.102 (0.002–1.248) | 0.086 | 60.3 | |||
| AG+GG | 12 (0.43) | 0.273 (0.052–1.254) | 0.110 | 38.9 | |||
| MAF | 13 (0.23) | 0.302 (0.106–0.866) | 0.023 | 66.8 |
anti-HBc – antibodies to core antigen of hepatitis B virus; HD – hemodialysis; MAF – minor allele frequency. Significant differences are indicated using bold font.