Figure 2.
Inducible ΔFosB overexpression in striatum blocks the anhedonic effects of CSDS in the ICSS test. ΔFosB-Control mice (n=3), but not ΔFosB-ON mice (n=3) tested 8 weeks after DOX discontinuation, show increases in ICSS thresholds on D1-10 and P1-5 compared to BL1-5. ***p<0.001 for within-group comparisons to baseline (BL1-5); ^p<0.05, ^^^p<0.001 for between-group comparisons.