Table 2.
ALS autopsy subjects studied for TREM2 expression in lumbar spinal cord
| Demographic Category | Metric | Correlation | P-value | |
|---|---|---|---|---|
| Age at onset (years, n=17) | Mean ± stdev (range) | 61±13 (29-75) | r=-0.03 | 0.9c |
| Survivala (months, n=18) | Mean ± stdev (range) | 31.3±28.0 (4-108) | r=-0.49 | 0.04c |
| Postmortem interval (hours, n=11) | Mean ± stdev (range) | 12.4±7.5 (2-28) | r=-0.45 | 0.17c |
| Site of onset (n=16) | % Bulbar (n) | 31 (5) | 0.21d | |
| Genetic causeb (n=18) | % With known gene (n) | 33 (6) | 0.21d | |
a
Survival defined as symptom onset to death or full-time ventilation.
b
3 subjects had SOD1 mutations (A4V, G85R, I133T) and 3 had C9ORF72 repeat expansions.
c
Spearman correlation, unadjusted for multiple comparisons.
d
Mann-Whitney U rank test, unadjusted for multiple comparisons.