Table 2.

Final Pathologic Findings on Surgery Cohort: 6 of 8 patients underwent surgery for progression on follow-up MMG and MRI. 5 of 8 patients had stage I IDC at surgical intervention, including 3 of whom showed increasing mass-like enhancement, one showed increasing extent of disease, and one showed extensive disease that did not continue to respond to endocrine therapy. One patient developed a contralateral mammographically occult finding during surveillance that showed DCIS on MRI-directed core biopsy (patient 9).

Study ID	Time to Surgery (mos)	Initial DCIS Grade	Surgical Recommendation at Presentation	Surgical Indication	Outcome	Pathology	Stage
1	17.4	Intermediate	Mastectomy	Elective	Lumpectomy	0.7 cm low grade DCIS ER+/PR+	0
2	15.9	Low	Mastectomy	Imaging progression	Left: Lumpectomy	1.2 cm low grade DCIS	0
5	70	Intermediate/Low	Mastectomy	Imaging Progression	Mastectomy with sentinel node bx	7 mm multifocal intermediate grade IDC ER+/PR+, Her2neu− with 2.1 cm low-int grade DCIS	I
6	10.1	Low	Mastectomy	Limited imaging response	Mastectomy with sentinel node bx	multi focal IBC up to 4 mm ER+/PR−, Her2Neu− and 6 cm high grade DCIS	I
9	29.8	Low/Intermediate	Right: Mastectomy Left: Lumpectomy	Imaging Progression	Right: Lumpectomy with sentinel node bx Left: Lumpectomy	Right: 1.7 cm IDC ER+/PR+, Hcr2Neu− and 2.6 cm int to high grade DCIS; Left: 2.4 cm intermediate grade DCIS	Right: Stage I Left: Stage 0
10	16.5	Intermediate	Mastectomy	Imaging Progression	Lumpectomy with sentinel node biopsy	6 cm high grade DCIS ER+/PR+	0
11	39.4	Intermediate	Lumpectomy	Imaging Progression	Lumpectomy with sentinel node bx	5 mm intermediate grade IDC ER+/PR, Her2Neu + and extensive high grade DCIS	I
12	26.9	High	Mastectomy	Imaging Progression	Lumpectomy with sentinel node bx	8 mm high grade IDC ER−/PR−, Her2Neu + and multifocal microscopic high grade comedo DCIS	I