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. Author manuscript; available in PMC: 2014 Jul 8.
Published in final edited form as: Lab Invest. 2008 Dec 15;89(2):131–141. doi: 10.1038/labinvest.2008.120

Figure 3.

Figure 3

Lack of follistatin in keratinocytes affects skin homeostasis of adult mice. (a) Masson trichrome-stained histological sections of tail skin of adult control and Fst mutant mice are shown. Morphometric analysis of tail skin revealed a significant increase in epidermal thickness in Fst mutant mice (**P=0.0093). (b) Increased number of BrdU-positive keratinocytes in tail skin of mutant mice. Arrows indicate stained nuclei. BrdU-positive cells per mm of basement membrane were counted (*P =0.0263). (c) Expression of keratin 14 (K14; first panel, green) and keratin 10 (K10; first panel, red) is similar in control and mutant mice. Fst mutant mice show interfollicular expression of keratin 6 (K6; second panel). Nidogen expression is unaltered in mutant mice (third panel). Dotted line indicates epidermal–dermal border. (a–c) Bar = 50 µm. E: epidermis; D: dermis; HF: hair follicle. (a, b) N = number of mice. Results shown are mean ± s.e.m.