Table 1.
Augmenter of liver regeneration from yeast to man
| Homo Sapiens (Human) | Mus Musculus (Mouse) | Rattus Norvegicus (Rat) | Saccharomyces cerevisae (Yeast) | |
| Description | Augmenter of liver regeneration (ALR)/growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) (GFER)/ hepatic regenerative stimulation substance (HSS)/hepatopoietin (HPO) | Augmenter of liver regeneration (Alr)/growth factor, erv1 (S. cerevisiae)- like (augmenter of liver regeneration) (Gfer) | Augmenter of liver regeneration (ALR)/ growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) (Gfer) | Saccharomyces cerevisiae ERV1 (scERV1)/flavin-linked sulfhydryl oxidase localized to the mitochondrial intermembrane space, has a role in the maturation of cytosolic iron-sulphur proteins; ortholog of human hepatopoietin (ALR) |
| Genomic Location | Chromosome: 16 Cytogenetic: 16p13.3-p13.12 | Chromosome: 17 Cytogenetic: 17 A3.3 | Chromosome: 10 Cytogenetic: 10q12 Genetic: 17 10.0 cM | Chromosome: VII |
| Peptide Length | 205 aa (23 ku) 125 aa (15 ku) | 198 aa | 125 aa (15 ku) | 189 aa (22 ku) |
| Protein Function | In liver regeneration and spermatogenesis | In liver regeneration and spermatogenesis | In liver regeneration and spermatogenesis | Essential for the biogenesis of mitochondria, cell viability and for vegetative growth |
| Protein Subunit | Homodimer/Heterodimer | Homodimer | Homodimer | Homodimer |
| Protein Similarity | Belongs to ERV1/ALR family | Belongs to ERV1/ALR family | Belongs to ERV1/ALR family | Belongs to ERV1/ALR family |
| Percentage of similarity to human | 85.6% [The comparison with human is based on nucleic acid (GeneCard for GFER)] 87.20% [The comparison with human is based on amino acid sequence (UniGene)] | 85.87% [The comparison with human is based on nucleic acid (GeneCard for GFER)] 85.60% [The comparison with human is based on amino acid sequence (UniGene)] | 52.85% [The comparison with human is based on nucleic acid (GeneCard for GFER)] 46.85% [The comparison with human is based on amino acid sequence (UniGene)] | |
| Subcellular Location | Nucleus (15 ku) Cytosol (23 ku) Mitochondrial intermembrane space (23 ku) | Mitochondrial intermembrane space | Cytosol Mitochondrial intermembrane space | Cytosol Mitochondrial intermembrane space |