Table 1.
Profiles and initial laboratory data of patients with and without retinopathy during IFN-ribavirin combination therapy1
| Total | Retinopathy (+) | Retinopathy (-) | |
| Patients | |||
| Number | 73 | 14 | 59 |
| Age (yr) | 53.4 ± 10.9 | 56.3 ± 10.5 | 52.8±38.6 |
| Gender (M/F) | 47/26 | 10/4 | 37/22 |
| Hypertension (Yes/No)a | 15/58 | 5/8 | 10/49 |
| Diabetes mellitus (Yes/No) | 2/71 | 1/13 | 1/58 |
| Peripheral blood count | |||
| Platelet count (×104/mm3) | 15.3 ± 6.0 | 12.5 ± 10.5 | 15.9 ± 38.6 |
| White blood cell (×103/mm3) | 46.9 ± 12.6 | 46.5 ± 13.0 | 48.6 ± 10.9 |
| Hemoglobin (×g/dL) | 14.0 ± 1.3 | 14.0 ± 1.0 | 14.0 ± 1.4 |
| Prothrombin time (%) | 90.2 ± 13.3 | 87.1 ± 13.3 | 90.8 ± 13.3 |
| ALT (IU/L) | 109.4 ± 78.2 | 104.1 ± 41.0 | 110.4 ± 83.6 |
| Viral factors | |||
| Genotype (type 1/type 2)2 | 45/26 | 33/24 | 12/2 |
| Viral load (kcopies/mL) | 592.3 ± 271.2 | 505.6 ± 309.1 | 607.5 ± 271.2 |
| Pretreatment/ Arteriosclerotic | 12/61 | 7/7 | 5/54 |
| changes in optic fundi (Yes/No) | |||
| Response to therapy (SVR/non-SVR) | 38/35 | 5/9 | 33/26 |
1 Data are expressed as mean ± SD.
2
Genotype could not be determined in 2 patients.
a
P = 0.004