Table 4.
Survival rates and results of uni- and multivariate analysis (treatment-related variables)
| OAS (%) | CSS (%) | DFS(%) | LRS (%) | DRS (%) | ||
| Adjuvant therapy | ||||||
| Postop RCT | 5 yr / 10 yr: | 47.6 / 35.6 | 59.0 / 48.4 | 40.2 / 34.0% | 66.1 / 64.1 | 82.2 / 82.2 |
| Preop RCT | 5 yr / 10 yr: | 43.9 / 38.0 | 62.6 / 62.6 | 45.4 / 39.3 | 69.8 / 69.8 | 92.8 / 92.8 |
| uni- / multivariate: P = | 0.82 / NS | 0.56 / NS | 0.61 / NS | 0.96 / NS | 0.12 / NS | |
| Protocol | ||||||
| NIH | 5 yr / 10 yr: | 60.7 / 45.2 | 72.5 / 59.4 | 49.8 / 44.2 | 84.1 / 84.1 | 73.2 / 73.2 |
| ARO | 5 yr / 10 yr: | 26.9 / 21.5 | 45.6 / 36.5 | 24.5 / 16.3 | 67.6 / 67.6 | 64.0 / 64.0 |
| uni- / multivariate: P = | < 0.001 / NS | 0.003 / 0.004 | 0.002 / NS | 0.024 / NS | 0.57 / NS | |
| multivariate risk ratio: | ARO: 2.66 | |||||
| (CI 1.37 – 5.21) | ||||||
| Surgery | risk ratio: | |||||
| LAR | 5 yr / 10 yr: | 36.4 / 25.9 | 49.5 / 41.1 | 27.8 / 22.7 | 64.7 / 64.7 | 81.3 / 81.3 |
| APR | 5 yr / 10 yr: | 35.2 / 26.0 | 46.7 / 39.9 | 27.6 / 22.9 | 52.4 / 51.1 | 86.4 / 86.4 |
| uni- / multivariate: P = | 0.4 / NS | 0.51 / NS | 0.27 / NS | 0.015 / 0.039 | 0.6 / NS | |
| multivariate risk ratio: | LAR: 1.3 | |||||
| (CI 1.01 – 1.60) | ||||||
| R status | ||||||
| R0 | 5 yr / 10 yr: | 53.2 / 40.3 | 64.2 / 55.1 | 45.6 / 39.5 | 66.2 / 64.5 | 91.2 / 91.2 |
| R1 or R2 | 5 yr / 10 yr: | 14.2 / 14.2 | 20.7 / 20.7 | 17.3 / 17.3 | 62.9 / 62.9 | 51.2 / 51.2 5 |
| uni- / multivariate: P = | < 0.001 / NS | 0.011 / (0.09) | < 0.001 / 0.026 | 0.95 / NS | < 0.001 / NS | |
| multivariate risk ratio: | R1/R2: 1.65 | R1/R2: 3.45 | ||||
| (CI 0.91 – 3.10) | (1.56 – 7.96) | |||||
Risk ratio with confidence interval (CI) is given if multivariate analysis (step down analysis) revealed a significant result. Five- and 10- year survival rates are given as OAS, CSS, DFS, LRS and DRS.