Table 6.
Anemia and hemoglobin increase versus decrease during radiotherapy (subgroup analysis of 199 patients with documented hemoglobin values before and after radiotherapy)
| OAS (%) | CSS (%) | DFS(%) | LRS (%) | DRS (%) | ||
| Anemia before RCT | ||||||
| No | 5 yr / 10 yr: | 44.6 / 31.4 | 66.4 / 66.4 | 41.5 / 33.7 | 76.6 / 76.6 | 74.9 / 74.9 |
| Yes | 5 yr / 10 yr: | 49.5 / 47.2 | 55.4 / 45.6 | 48.5 / 39.2 | 61.5 / 59.6 | 88.1 / 88.1 |
| uni- / multivariate: P = | 0.39 / NS | 0.14 / NS | 0.83 / 0.04 | 0.04 / NS | 0.01 / NS | |
| multivariate risk ratio: | anemia present: 0.76 | |||||
| (CI 0.57 – 0.99) | ||||||
| Anemia after RCT | ||||||
| No | 5 yr / 10 yr: | 47.5 / 34.0 | 57.4 / 48.4 | 42.5 / 34.7 | 87.6 / 87.6 | 62.7 / 60.7 |
| Yes | 5 yr / 10 yr: | 47.0 / 41.5 | 64.7 / 59.3 | 39.6 / 35.9 | 80.0 / 80.0 | 73.0 / 73.0 |
| uni- / multivariate: P = | 0.76 / NS | 0.56 / NS | 0.83 / NS | 0.12 / NS | 0.06 / NS | |
| multivariate risk ratio: | ||||||
| Hemoglobin (Hb) increase or decrease during RT | ||||||
| Hb increase | 5 yr / 10 yr: | 67.7 / 59.3 | 58.8 / 51.4 | 45.2 / 45.2 | 83.8 / 83.8 | 62.8 / 62.8 |
| Hb decrease | 5 yr / 10 yr: | 35.3 / 35.3 | 38.7 / 33.9 | 36.2 / 36.2 | 73.9 / 73.9 | 75.9 / 75.9 |
| uni- / multivariate: P = | < 0.01 / NS | < 0.01 / NS | 0.08 / 0.04 | 0.38 / NS | 0.79 / NS | |
| multivariate risk ratio: | Hb decrease: 1.97 | |||||
| (CI 1.02 – 3.43) | ||||||
Survival rates and results of the uni- and multivariate analysis as well as risk ratio with confidence interval (CI) are given if multivariate analysis (step down analysis) revealed a significant result. Five- and 10-year survival rates are given as OAS, CSS, DFS, LRS and DRS