Table 3.
Results of biochemical examination of patients
| Stage | 1 | 2 | 3 | 4 | P |
| n | 113 | 68 | 18 | 38 | |
| Platelet (× 104 μL) | 18.0 ± 8.0 | 13.9 ± 6.6 | 12.1 ± 5.7 | 9.9 ± 5.6 | < 0.001 |
| AST (IU) | 47.3 ± 31.9 | 51.6 ± 27.2 | 63.8 ± 33.4 | 95.9 ± 142.2 | 0.001 |
| ALT (IU) | 60.9 ± 59.3 | 61.0 ± 40.5 | 75.8 ± 51.0 | 86.8 ± 135.7 | 0.023 |
| ALB (g/dL) | 3.9 ± 1.0 | 3.6 ± 1.3 | 3.8 ± 1.0 | 3.3 ± 1.1 | 0.036 |
| HA (ng/mL)1 | 56.7 ± 65.8 | 89.2 ± 112.0 | 113.8 ± 125.8 | 509.3 ± 404.7 | < 0.001 |
| IV collagen (ng/mL)2 | 121.0 ± 57.5 | 149.9 ± 67.9 | 176.8 ± 129.2 | 229.7 ± 108.8 | 0.020 |
| IV collagen 7S (ng/mL)2 | 5.5 ± 1.8 | 6.0 ± 1.6 | 8.9 ± 2.9 | 8.0 ± 2.1 | 0.001 |
| P-III-P (U/mL)2 | 0.79 ± 0.19 | 0.88 ± 0.30 | 1.23 ± 0.60 | 1.02 ± 0.29 | 0.023 |
Results are given as mean ± SD.
1
HA was measured in 57 patients;
2
IVcollagen, IVcollagen 7S, and P-III-P were measured in 52 patients. AST: asparate aminotransferase; ALT: alanine aminotransferase; ALB: albumin; HA: hyaluronic acid.