Table 1.
Commonly available serological markers for assessing liver injury[8]
| Group | Marker/panel | Comments |
| 1 | Prothrombin index | Highest diagnostic accuracy (cirrhosis) 86% |
| 1 | PGAA | Diagnostic accuracy 80% |
| 1 | AST/ALT ratio | Increase strongly correlated with decrease in hepatic function AST/ALT > 1 can diagnose cirrhosis with sensitivity of 77.8% and specificity 96.9%, but misclassified 7% as having cirrhosis and failed to diagnose 11% |
| 1 | FibroTest | Sensitivity 75%, specificity 85% |
| 1 | APRI | Predicts fibrosis in 51% patients Predicts cirrhosis in 81% patients |
| 2 | Hyaluronic acid (HA) | Only group 2 marker to show encouraging results, with a positive predictive value similar to Child-Pugh |