Table 3.
Serum chemistry analysis after administration of Chunggan extract for 4 wk
| Number of dogs |
Male (12) |
Female (12) |
||||||
| CGX (mg/kg per day) | 0 | 100 | 200 | 400 | 0 | 100 | 200 | 400 |
| AST (IU/L) | 37.0 ± 3.4 | 36.3 ± 2.0 | 40.3 ± 14.2 | 41.3 ± 8.3 | 40.6 ± 8.5 | 34.3 ± 5.7 | 37.0 ± 4.3 | 40.0 ± 9.5 |
| ALT (IU/L) | 57.6 ± 7.3 | 48.6 ± 8.1 | 49.3 ± 29.7 | 65.6 ± 24.0 | 38.0 ± 7.0 | 46.6 ± 16.2 | 44.0 ± 1.7 | 33.6 ± 9.0 |
| ALP (IU/L) | 328 ± 46 | 299 ± 102 | 390 ± 221 | 238 ± 74 | 271 ± 104 | 391 ± 93 | 377 ± 159 | 174 ± 43 |
| BUN (mg/dL) | 18.2 ± 1.3 | 20.1 ± 3.1 | 22.8 ± 3.6 | 19.3 ± 3.5 | 13.4 ± 1.9 | 17.6 ± 2.6 | 13.9 ± 3.9 | 24.4 ± 4.8a |
| Creatinine (mg/dL) | 1.05 ± 0.1 | 1.20 ± 0.1 | 1.23 ± 0.1 | 1.18 ± 0.1 | 1.03 ± 0.2 | 1.15 ± 0.1 | 1.09 ± 0.1 | 1.11 ± 0.1 |
| Glucose (mg/dL) | 99.0 ± 15.5 | 115.6 ± 5.1 | 112.3 ± 11.9 | 110.7 ± 4.2 | 114 ± 14 | 121 ± 10.2 | 117 ± 5.6 | 116 ± 26.1 |
| Total chol. (mg/dL) | 252 ± 30 | 223 ± 34 | 260 ± 25 | 217 ± 51 | 299 ± 73 | 296 ± 34 | 263 ± 24 | 261 ± 58 |
| Total bilirubin (mg/dL) | 0.23 ± 0.1 | 0.27 ± 0.1 | 0.23 ± 0.1 | 0.30 ± 0.1 | 0.30 ± 0.1 | 0.30 ± 0.0 | 0.30 ± 0.1 | 0.33 ± 0.1 |
| Total protein (g/dL) | 7.83 ± 0.2 | 7.37 ± 0.2 | 7.33 ± 0.2 | 7.37 ± 0.3 | 7.60 ± 0.3 | 7.47 ± 0.6 | 7.40 ± 0.4 | 7.53 ± 0.2 |
| Albumin (g/dL) | 4.73 ± 0.3 | 4.33 ± 0.2 | 4.47 ± 0.1 | 4.60 ± 0.4 | 4.77 ± 0.3 | 4.50 ± 0.3 | 4.63 ± 0.3 | 4.57 ± 0.2 |
| AG ratio | 1.53 ± 0.2 | 1.43 ± 0.2 | 1.60 ± 0.2 | 1.67 ± 0.3 | 1.70 ± 0.1 | 1.50 ± 0.1 | 1.70 ± 0.1 | 1.57 ± 0.1 |
| C.phosphokinase (IU/L) | 133 ± 15 | 130 ± 39 | 171 ± 89 | 157 ± 48 | 199 ± 30 | 116 ± 24 | 155 ± 37 | 144 ± 23 |
| Triglyceride (mg/dL) | 25.0 ± 3.0 | 35.6 ± 24.8 | 30.0 ± 3.6 | 287 ± 7.2 | 36.0 ± 16.6 | 28.4 ± 9.5 | 36.0 ± 5.2 | 47.3 ± 17.1 |
| Calcium (mg/dL) | 14.8 ± 0.5 | 14.5 ± 0.5 | 14.6 ± 0.3 | 14.4 ± 0.2 | 14.5 ± 0.5 | 14.7 ± 0.9 | 14.1 ± 0.4 | 14.6 ± 0.7 |
| Inorganic pho. (mg/dL) | 3.33 ± 1.1 | 4.43 ± 0.3 | 4.23 ± 0.3 | 4.43 ± 0.6 | 3.80 ± 0.5 | 3.90 ± 0.6 | 4.03 ± 0.8 | 3.63 ± 0.3 |
| LDH (IU/L) | 105 ± 45.7 | 132 ± 73.5 | 91.7 ± 32.8 | 106 ± 60.3 | 80.0 ± 11.5 | 68.3 ± 9.7 | 146 ± 60.7 | 146 ± 126.1 |
| GGT (IU/L) | 4.63 ± 0.3 | 3.93 ± 1.3 | 4.03 ± 0.4 | 4.37 ± 1.3 | 4.93 ± 1.0 | 5.13 ± 0.4 | 4.57 ± 1.0 | 5.53 ± 0.5 |
| Sodium (mmol/dL) | 148 ± 2.0 | 146 ± 1.1 | 144 ± 2.1 | 144 ± 0.6 | 146 ± 1.2 | 148 ± 1.00 | 147 ± 2.0 | 147 ± 0.4 |
| Potassium (mmol/dL) | 4.21 ± 0.1 | 4.32 ± 0.1 | 4.31 ± 0.2 | 4.18 ± 0.2 | 4.08 ± 0.23 | 3.95 ± 0.2 | 4.24 ± 0.3 | 4.42 ± 0.4 |
| Chloride (mmol/dL) | 116 ± 1.1 | 115 ± 2.5 | 115 ± 2.3 | 116 ± 0.6 | 117 ± 1.5 | 114 ± 1.5 | 114 ± 3.2 | 114 ± 1.5 |
After administration of Chunggan extract (CGX) for 4 wk, serum chemistry was analysed to compare CGX-treated groups to the control group. AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; BUN: Blood urea nitrogen; AG ratio: Albumin globulin ratio; LDH: Lactate dehydrogenase; GGT: Gamma glutamyl transferase.
a
P < 0.05 among BUN in female grops treated with 0 mg, 100 mg, 200 mg and 400 mg CGX.