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. 2006 Aug 14;12(30):4794–4806. doi: 10.3748/wjg.v12.i30.4794

Table 4.

Drugs for the treatment of CD

Drug Methotrexate
Dosage 25 mg/wk i.m., if remission is achieved reduce to 15 i.m. (or s.c.)
Indications Maintenance, chronically active disease, steroid-refractory and steroid-dependency, fistulae
Important side effects Nausea, abdominal pain, diarrhea, stomatitis; hepatitis, liver fibrosis; hypersensivity pneumonitis
Monitoring Liver function and full blood count monthly for the first two months, if normal then every two months throughout therapy
Pregnancy Strictly prohibited
Comments Entire therapeutic efficacy is observed mostly after 2-4 mo; consider folic acid supplementation with 2.5-5 mg/d; ensure adequate birth control; allow 3 mo time before pregnancy or conceiving