Dosage |
5 mg/kg per infusion; usually started at wk 0, 2, and 6 and then repeated every 8 wk if necessary |
Indications |
Chronically active disease, steroid-refractory and steroid-dependency, maintenance, fistulae |
Important side effects |
Nausea, headache, abdominal pain, infections, sepsis; infusions reactions (early or delayed), reactivation of tuberculosis |
Monitoring |
Vital signs around infusion |
Pregnancy |
Unknown |
Comments |
Exclude tuberculosis before infusions, consider concommittant use of imunosuppressants (azathioprine) to reduce antibody formation |