| Lipid ligands |
| TLR1 |
Tri-acyl lipopeptides (bacteria, mycobacteria) |
| TLR2 |
Lipoprotein/lipopeptides (a variety of pathogens) |
|
Peptidoglycan (Gram-positive bacteria) |
|
Lipoteichoic acid (Gram-positive bacteria) |
|
Lipoarabinomannan (mycobacteria) |
|
A phenol-soluble modulin (Staphylococcus epidermidis) |
|
Glycoinositolphospholipids (Trypanosoma Cruzi) |
|
Glycolipids (Treponema maltophilum) |
|
Porins (Neisseria) |
|
Zymosan (fungi) |
|
Atypical LPS (Leptospira interrogans and Porphyromonas gingivalis) |
|
Hemagglutinin (measles) |
| TLR4 |
LPS (Gram-negative bacteria) |
|
Fusion protein (respiratory syncytial virus) |
|
Envelope proteins (mouse mammary tumor virus) |
|
HSP60 (Chlamydia pneumoniae) |
| TLR6 |
Di-acyl lipopeptides (mycoplasma) |
| Nucleic acid ligand |
| TLR3 |
Double-stranded RNA (virus) |
| TLR7 or 8 |
U-rich ssRNA |
| TLR9 |
CpG DNA (bacteria) |
| Protein ligand |
| TLR5 |
Flagellin (bacteria) |
| Uropathogenic bacteria |
| TLR11 |
Uropathogenic bacteria |
| Ligand unknown |
| TLR10 |
? |
