Table 1.
H pylori gastric colonization and the corresponding serologic responses to FlaA and r-FlgK of H pylori in different mouse groups
| Mean (SD) | W group | M group | I group |
| 1-wk mouse groups | (n = 15) | (n = 15) | (n =15) |
| Anti-FlaA (A) | 0.312 (0.141) | 0.301 (0.115) | 0.289 (0.128) |
| Anti-r-FlgK (A)abc | 0.459 (0.066) | 0.329 (0.085) | 1.258 (0.692) |
| HPD (0-15)ac | 5.35 (2.08) | 3.65 (2.87) | 5.24 (2.15) |
| 4-week mouse groups | (n = 13) | (n = 14) | (n = 14) |
| Anti-FlaA (A) | 0.345 (0.105) | 0.324 (0.115) | 0.298 (0.101) |
| Anti-r-FlgK (A)abc | 0.682 (0.395)1 | 0.351 (0.052) | 1.325 (0.171) |
| HPD (0-15)ab | 6.59 (2.78)1 | 4.25 (2.15) | 3.89 (1.85)1 |
W group: mice challenged with wild-type H pylori; M group: mice challenged with isogenic flgK-mutant; I group: mice received pre-immunization of r-FlgK before challenge of wild-type H pylori; HPD: total H pylori density of the mice's stomachs by histology. The value of anti-FlaA and anti-r-FlgK was indicated as optical density (A) checked by ELISA with a 1:1000 dilution of serum.
indicated significant difference between W and M mice groups;
between W and I mice groups;
between I and M mice groups (One way ANOVA test with Bonferroni’s method, P < 0.05);
indicated significant difference of this parameter between the 1-wk and the 4-wk samples within the same mouse group (Student’s t test, P < 0.05).