Table 2.
Significantly overexpressed genes (over 2-fold) in malignant pancreas
| Gene symbol | Gene description |
Mean fold expression ratios |
||
| Malignant | PCL/ | PT/ | ||
| Panc/others | CCL | NormPanc | ||
| PLAT | Plasminogen activator, tissue-type | 6.22 | 4.36 | 6.74 |
| KRT7 | Keratin 7 | 5.72 | 4.92 | 3.97 |
| CD74 | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | 5.44 | 1.61 | 8.00 |
| MMP7 | Matrix metalloproteinase 7 (matrilysin, uterine) | 5.36 | 3.73 | 5.70 |
| LCN2 | Lipocalin 2 (oncogene 24p3), NGAL | 5.25 | 8.32 | 3.36 |
| HLA-G | HLA-G histocompatibility antigen, class I, G | 4.04 | 1.57 | 4.32 |
| IGHG3 | Immunoglobulin heavy constant gamma 3 | 3.95 | 0.94 | 11.81 |
| HLA-DRA | Major histocompatibility complex, class II, DR alpha | 3.70 | 1.57 | 7.01 |
| TIMP1 | Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) | 3.50 | 1.61 | 9.20 |
| ITGA3 | Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 3.48 | 3.00 | 2.40 |
| ITGB4 | Integrin, beta 4 | 3.36 | 1.16 | 4.34 |
| KRT19 | Keratin 19 | 3.27 | 1.34 | 2.98 |
| CTSD | Cathepsin D (lysosomal aspartyl protease) | 3.21 | 2.75 | 2.89 |
| CASP4 | Caspase 4, apoptosis-related cysteine protease | 3.10 | 2.43 | 1.80 |
| IGFBP3 | Insulin-like growth factor binding protein 3 | 3.08 | 3.53 | 1.87 |
| PLAU | Plasminogen activator, urokinase | 3.08 | 2.83 | 2.01 |
| MMP11 | Matrix metalloproteinase 11 (stromelysin 3) | 2.96 | 1.11 | 7.22 |
| DTR | Diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) | 2.84 | 1.74 | 3.33 |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.76 | 1.65 | 3.17 |
| LAMA4 | Laminin, alpha 4 | 2.74 | 2.14 | 3.30 |
| ITGB8 | Integrin, beta 8 | 2.59 | 2.31 | 4.44 |
| IFITM1 | Interferon induced transmembrane protein 1 (9-27) | 2.41 | 5.47 | 7.10 |
| AXL | AXL receptor tyrosine kinase | 2.35 | 1.63 | 2.91 |
| ITGAE | Integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | 2.31 | 1.58 | 3.56 |
| CD59 | CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) | 2.26 | 2.11 | 2.95 |
| KRT10 | Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris) | 2.09 | 2.18 | 1.60 |
| CYR61 | Cysteine-rich, angiogenic inducer, 61 | 2.03 | 2.41 | 1.22 |
| PTGES | Prostaglandin E synthase | 2.03 | 2.84 | 1.11 |
| HIF1A | Hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 2.01 | 1.24 | 2.87 |