Figure 4.

Effect of vitamin restriction and cisplatin on oxidative stress, structural and functional integrity of the intestinal mucosa. Levels of lipid peroxides (TBARS) and protein carbonyls are shown in panel A. Lowered activities of alkaline phosphatase (Panel B), lys, ala-dipeptidyl aminopeptidase (Panel C), are indicative of compromised functional integrity. Panel D indicates the ratio of villus height: crypt depth in control and vitamin restricted rats treated with saline and cisplatin, indicating structural integrity of the mucosa.