Table 1.

Classification of pancreatic endorcrine tumous

Tumor	Hormone produced	Percent malignant	Clinical features	5 yr survival	Localization	Treatment
Insulinoma	Insulin proinsulin	10%	Hypoglycemia, neuroglycopenic symptoms	97%	EUS, intraoperative ultrasound	Surgical resection, chemotherapy, dextrose
Gastrinoma	Gastrin	60%-90%	Peptic ulcer disease, diarrhea	60%-70%	SRS, SPECT, EUS	Surgical resection, PPI, somatostatin
Glucagonoma	Glucagon	50%-90%	Necrolytic migratory erythema, diabetes, DVT, depression	50%-60%	CT w/contrast, EUS	Surgical resection, nutritional support, somatostatin, chemotherapy, insulin
VIPoma	Vasoactive intestinal peptide	40%-70%	Secretory diarrhea, hypokalemia, achlorhydria	50%	CT Scan, SRS	Somatostatin, correction ofelectrolytes, hydration, surgical resection
Somatostatinoma	Somatostatin	70%-80%	DM, cholelithiasis, steatorrhea	40%	CT, EUS, SRS	Surgical resection chemotherapy, somatostatin
Non-functional tumors	Pancreatic polypeptide	60%-80%	Abdominal pain, weight loss, jaundice	50%	CT, MRI	Surgical resection