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Simplified model of the parietal cell showing the current mechanisms involved in acid secretion in comparison to a resting cell. The Ca2+-sensing receptor (CaSR) and the histamine receptor are located on the basolateral membrane. HCl secretion is mediated by H+ extrusion via the H+,K+-ATPase coupled with Cl- secretion via an apical channel. Activation of the CaSR causes acid secretion via the H+, K+-ATPase.
