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. 2006 May 28;12(20):3229–3236. doi: 10.3748/wjg.v12.i20.3229

Figure 2.

Figure 2

Schematic of acid secretion. A: Classically defined pathway of acid secretion: Gastrin released from the G cell binds to receptors on the ECL cell causing histamine release from the ECL cell. The histamine binds to receptors on the parietal cell and stimulates proton efflux; B: Modified model of acid secretion involving a functional CaSR on the basolateral membrane of both the G cell and parietal cell. Acid secretion can be activated directly by the CaSR on the parietal cell or via the G cell pathway.