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editorial
. 2006 Apr 28;12(16):2477–2486. doi: 10.3748/wjg.v12.i16.2477

Figure 3.

Figure 3

Schematic illustration of the proposed gut layers which are preferentially affected with: (1) Thermal stimuli (mucosa - dark grey and submucosa - light grey); (2) Mechanical stimuli (circular muscle layer - hatched grey and longitudinal muscle layer - prickled grey); (3) Electrical stimuli (all layers depending on stimulus intensity). Perfusion of the esophagus with acid (curved arrows) gives the possibility to evoke peripheral and (mainly) central sensitization (illustrated with stars).