Table 2.
Univariate analysis of survival
| Variable | 5-yr survival (%) | P Value | |
| Age | < 60 vs ≥ 60 | 40.0 vs 44.9 | 0.912 |
| Gender | male vs female | 42.3 vs 45.5 | 0.872 |
| Operative procedure | hepatectomy vs bile duct resection | 42.2 vs 60.0 | 0.430 |
| Histopathologic Grading1 | G2, G3 vs G1 | 37.5 vs 46.0 | 0.393 |
| Lymphatic vessel invasion | present vs absent | 37.4 vs 75.0 | 0.076 |
| Venous invasion | present vs absent | 36.4 vs 49.7 | 0.185 |
| Perineural invasion | present vs absent | 36.3 vs 68.6 | 0.064 |
| Microscopic resection margin2 | em1 vs em0 | 31.7 vs 83.3 | 0.040 |
| VEGF-C expression | positive vs negative | 23.3 vs 70.5 | 0.036 |
| Lymph node metastasis (Including micrometastasis) | positive vs negative | 8.5 vs 72.5 | 0.0004 |
| Lymph node metastasis (except micrometastasis) | positive vs negative | 0.0 vs 60.2 | 0.0017 |
1
According to the TNM staging system. Histopathological Grading: G1 Well differentiated, G2 Moderately differentiated, G3 Poorly differentiated.
2
According to the Japanese Society of Biliary Surgery. General Rules for Surgical and Pathological Studies on Cancer of the Biliary Tract. em0: no tumor invades within 5 mm from resected margin; em1: tumor invades within 5mm from resected margin.