Table 3.
Morbidity and mortality
| Outcome | Type of studies included in the meta-analysis | Trials (n) |
LADG |
CODG |
Pooled results OR (95% CI) | Interpretation | Test for heterogeneity | ||
| Events | Patients (n) | Events | Patients (n) | ||||||
| Overall complications | RCTs | 4 | 16 | 82 | 30 | 80 | 0.41 (0.20, 0.85) Z = 2.41, P = 0.02 | L < C | χ2 = 2.52, df = 3 P = 0.47, I2 = 0% |
| Overall | 13 | 58 | 535 | 97 | 519 | 0.54 (0.37, 0.77) Z = 3.37, P < 0.001 | L < C | χ2 = 9.11, df = 12 P = 0.69, I2 = 0% | |
| Anastomotic leakage | RCTs | 2 | 0 | 44 | 3 | 43 | 0.23 (0.02, 2.18) Z = 1.28, P = 0.20 | L = C | χ2 = 0.07, df = 1 P = 0.80, I2 = 0% |
| Overall | 7 | 2 | 385 | 10 | 365 | 0.38 (0.12, 1.18) Z = 1.67, P = 0.10 | L = C | χ2 = 0.96, df = 6 P = 0.99, I2 = 0% | |
| Anastomotic stenosis | RCTs | 2 | 0 | 38 | 2 | 37 | 0.31 (0.03, 3.11) Z = 1.00, P = 0.32 | L = C | χ2 = 0.00, df = 1 P = 1.00, I2 = 0% |
| Overall | 5 | 6 | 172 | 5 | 163 | 1.11 (0.35, 3.54) Z = 0.18, P = 0.86 | L = C | χ2 = 2.01, df = 4 P = 0.73, I2 = 0% | |
| Postoperative ileus | Overall | 6 | 2 | 267 | 13 | 264 | 0.27 (0.09, 0.84) Z = 2.26, P = 0.02 | L < C | χ2 = 1.40, df = 5 P = 0.92, I2 = 0% |
| Pulmonary complications | RCTs | 4 | 10 | 82 | 19 | 80 | 0.47 (0.20, 1.12) Z = 1.70, P = 0.09 | L = C | χ2 = 1.95, df = 3 P = 0.58, I2 = 0% |
| Overall | 8 | 12 | 260 | 22 | 271 | 0.54 (0.25, 1.15) Z = 1.59, P = 0.11 | L = C | χ2 = 3.66, df = 7 P = 0.82, I2 = 0% | |
| Wound infection | RCTs | 2 | 3 | 54 | 3 | 52 | 0.96 (0.18, 5.01) Z = 0.05, P = 0.96 | L = C | χ2 = 0.05, df = 1 P = 1.00, I2 = 0% |
| Overall | 9 | 9 | 448 | 13 | 421 | 0.69 (0.30, 1.57) Z = 0.89, P = 0.37 | L = C | χ2 = 3.00, df = 8 P = 0.93, I2 = 0% | |
| Mortality | Overall | 2 | 2 | 101 | 3 | 105 | 0.67 (0.11, 4.24) Z = 0.43, P = 0.67 | L = C | χ2 = 0.19, df = 1 P = 0.66, I2 = 0% |
L: Laparoscopy-assisted distal gastrectomy; C: Conventional open distal gastrectomy; OR: Odds ratio; CI: Confidence intervals; RCTs: Randomized controlled trials; df: Degree of freedom.