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Comparison of the tolerance variables in the four groups n (%)
| Side effect | Group 1 | Group 2 | Group 3 | Group 4 | P |
| Nausea | 17 (39.5) | 24 (53.3) | 24 (53.3) | 15 (34.1) | NS |
| Vomiting | 4 (9.3) | 10 (22.2) | 10 (22.2) | 8 (18.2) | NS |
| Disgusting1 | 10 (23.3) | 12 (26.7) | 12 (26.7) | 12 (27.3) | NS |
| Thirst1 | 6 (13.9) | 9 (20.0) | 9 (20) | 12 (27.2) | NS |
| Abdominal pain1 | 4 (9.3) | 4 (8.9) | 3 (6.6) | 5 (11.4) | NS |
| Anal pain1 | 1 (2.3) | 4 (8.9) | 1 (2.2) | 2 (4.5) | NS |
As moderate or severe.
