Table 4.
Allele and genotype frequencies of ARP, SPINK1 and CFTR gene polymorphisms in pancreatic cancers and controls
| Polymorphisms | Cases (n = 61) | Controls (n = 105) | |
| ARP | |||
| Allele frequencies | |||
| *1 | 4 (3.3) | 4 (2.0) | |
| *2 | 4 (3.3) | 7 (3.0) | |
| *3 | 111 (91.0) | 195 (93.0) | |
| *4 | 1 (0.8) | 0 (0.0) | |
| *5 | 1 (0.8) | 2 (1.0) | |
| *6 | 1 (0.8) | 0 (0.0) | |
| *7 | 0 (0.0) | 2 (1.0) | |
| CLUMP (T1): χ2 = 5.25 (df = 6), P = 0.52 | |||
| Genotype frequencies | |||
| *1*3 | 4 (6.6) | 4 (3.8) | |
| *2*3 | 4 (6.6) | 7 (6.7) | |
| *3*3 | 50 (82.0) | 90 (85.7) | |
| *3*4 | 1 (1.6) | 0 (0.0) | |
| *3*5 | 1 (1.6) | 2 (1.9) | |
| *3*6 | 1 (1.6) | 0 (0.0) | |
| *3*7 | 0 (0.0) | 2 (1.9) | |
| CLUMP (T1): χ2 = 5.29 (df = 27), P = 0.54 | |||
| SPINK1 (exon 3) | |||
| Allele frequencies | |||
| wt | 117 (95.9) | 206 (98.0) | |
| P55S | 4 (3.3) | 2 (1.0) | |
| N34S | 1 (0.8) | 2 (1.0) | |
| CLUMP (T1): χ2 = 2.36 (df = 2), P = 0.29 | |||
| Genotype frequencies | |||
| wt/wt | 56 (91.8) | 101 (96.2) | |
| wt/P55S | 4 (6.6) | 2 (1.9) | |
| wt/N34S | 1 (1.6) | 2 (1.9) | |
| CLUMP (T1): χ2 = 2.40 (df = 5), P = 0.30 | |||
| CFTR | |||
| Allele frequencies | |||
| wt | 119 (97.5) | 206 (98.0) | |
| ∆F508 | 3 (2.5) | 4 (2.0) | |
| CLUMP (T1): χ2 = 0.11 (df = 1), P = 1.0 | |||
| Genotype frequencies | |||
| wt/wt | 58 (95.1) | 101 (96.2) | |
| wt/∆F508 | 3 (4.9) | 4 (3.8) | |
| CLUMP (T1): χ2 = 0.11 (df = 2), P = 1.0 | |||
n (%)