Table 2.
TGF-β signaling pathway genes: overall associations with breast cancer risk, the breast cancer health disparities study
| Gene (SNP) | Genotype | Controls (n= 4,209) |
Cases (n= 3,524) |
ORa | (95 % CI) | pb | ||
|---|---|---|---|---|---|---|---|---|
| N | (%) | N | (%) | |||||
| RUNX1 (rs7279383) | CC | 3,098 | 73.6 | 2,647 | 75.1 | 1.00 | 0.032 (0.23) | |
| CG/GG | 1,110 | 26.4 | 876 | 24.9 | 0.89 | (0.80, 0.99) | ||
| RUNX1 (rs8127225) | TT | 2,591 | 61.6 | 2,117 | 60.1 | 1.00 | 0.029 (0.23) | |
| TC/CC | 1,612 | 38.4 | 1,407 | 39.9 | 1.11 | (1.01, 1.22) | ||
| RUNX2 (rs10948238) | CC/CT | 3,602 | 85.6 | 2,950 | 83.8 | 1.00 | 0.028 (0.42) | |
| TT | 604 | 14.4 | 571 | 16.2 | 1.15 | (1.01, 1.30) | ||
| RUNX2 (rs13201287) | GG/GA | 3,899 | 92.6 | 3,226 | 91.5 | 1.00 | 0.050 (0.69) | |
| AA | 310 | 7.4 | 298 | 8.5 | 1.18 | (1.00, 1.39) | ||
| RUNX3 (rs906296) | CC | 2,701 | 64.2 | 2,143 | 60.8 | 1.00 | 0.004 (0.03) | |
| CG/GG | 1,505 | 35.8 | 1,379 | 39.2 | 1.15 | (1.04, 1.26) | ||
| TGF-β1 (rs4803455) | CC | 1,400 | 35.3 | 1,193 | 37.0 | 1.00 | 0.023 (0.04) | |
| CA/AA | 2,561 | 64.7 | 2,032 | 63.0 | 0.89 | (0.81, 0.98) | ||
| TGF-β2 (rs6604609)c | TT | 3,455 | 82.1 | 3,009 | 85.4 | 1.00 | 0.0002 | |
| TA/AA | 753 | 17.9 | 515 | 14.6 | 0.80 | (0.71, 0.91) | ||
| TGF-βR1 (rs6478974) | TT/TA | 3,531 | 83.9 | 2,884 | 81.9 | 1.00 | 0.045 (0.19) | |
| AA | 677 | 16.1 | 639 | 18.1 | 1.13 | (1.00, 1.28) | ||
| TGF-βR2 (rs3773644)c | CC/CT | 3,767 | 89.5 | 3,072 | 87.2 | 1.00 | 0.004 | |
| TT | 441 | 10.5 | 452 | 12.8 | 1.21 | (1.05, 1.40) | ||
| TGF-βR3 (rs6678564) | GG | 3,523 | 83.7 | 3,004 | 85.2 | 1.00 | 0.03 (0.11) | |
| GC/CC | 685 | 16.3 | 520 | 14.8 | 0.87 | (0.77, 0.99) | ||
Bold text designates significant associations at the 0.05 level after adjustment for multiple comparisons
a
Adjusted for age, study center, and genetic admixture
b
Wald p-value for 1 df test; p-value adjusted for multiple comparisons (Bonferroni–Holm) in parentheses
c
Only one SNP evaluated for each gene, multiple comparisons not applicable