Table 3.
The Association of TGF-β signaling pathway genes and breast cancer risk stratified by menopausal status
| Gene (SNP) | Genotype | Pre/peri-menopause (n= 2,827) |
Post-menopause (n =4,679) |
p-intb | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n = 1,306) |
Cases (n = 1,521) |
ORa | (95 % CI) | Contros (n = 21,105) |
Cases (n = 2,574) |
ORa | (95 % CI) | |||||||
| N | (%) | N | (%) | N | (%) | N | (%) | |||||||
| RUNX1 | TT/TC | 1,480 | 97.3 | 1,273 | 97.5 | 1.00 | 2,515 | 97.7 | 2,033 | 96.6 | 1.00 | 0.10 (0.77) | ||
| (rs2268288) | CC | 41 | 2.7 | 33 | 2.5 | 0.88 | (0.55, 1.41) | 59 | 2.3 | 71 | 3.4 | 1.47 | (1.03, 2.09) | |
| RUNX3 | CC | 1,009 | 66.3 | 774 | 59.3 | 1.00 | 1,619 | 63.0 | 1,301 | 61.9 | 1.00 | 0.01 (0.08) | ||
| (rs906296) | CG/GG | 512 | 33.7 | 532 | 40.7 | 1.33 | (1.14, 1.55) | 952 | 37.0 | 802 | 38.1 | 1.05 | (0.93, 1.18) | |
| RUNX3 | GG/GA | 1,504 | 98.9 | 1,293 | 99.0 | 1.00 | 2,546 | 99.0 | 2,068 | 98.2 | 1.00 | 0.21 (1.00) | ||
| (rs4478762) | AA | 16 | 1.1 | 13 | 1.0 | 0.98 | (0.47, 2.05) | 27 | 1.0 | 37 | 1.8 | 1.71 | (1.04, 2.82) | |
Bold text designates significant associations at the 0.05 level (within strata) after adjustment for multiple comparisons
a
Odds Ratios adjusted for age, study, and genetic admixture (n = 7,506; missing observations: menopausal status (n = 227)
b
Interaction p-value (SNP × menopause); Bonferroni p-value for adjustment for multiple comparisons shown in parentheses