Table 4.
The Association of TGF-β signaling pathway genes and breast cancer risk stratified by proportion of Native American ancestry
| Gene (SNP) | Genotype | ≤0–28 % |
29–70 % |
71–100 % |
p-intb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/ control |
ORa | (95 % CI) | Case/ Control |
OR a | (95 % CI) | Case/ control |
ORa | (95 % CI) | |||
| RUNX1 | CC | 1,165/1,229 | 1.00 | 1,092/1,285 | 1.00 | 390/584 | 1.00 | 0.004 (0.04) | |||
| (rs7279383) | CG/GG | 530/641 | 0.87 | (0.76, 1.00) | 288/419 | 0.82 | (0.69, 0.97) | 58/50 | 1.75 | (1.17, 2.63) | |
| TGF-β1 | CC | 772/866 | 1.00 | 379/516 | 1.00 | 102/141 | 1.00 | 0.42 (0.84) | |||
| (rs1800469) | CT | 692/759 | 1.01 | (0.88, 1.17) | 692/854 | 1.11 | (0.94, 1.31) | 206/299 | 0.95 | (0.69, 1.30) | |
| TT | 1,90/216 | 0.96 | (0.77, 1.20) | 295/313 | 1.29 | (1.04, 1.58) | 133/193 | 0.92 | (0.65, 1.30) | ||
a
Odds Ratios adjusted for age and study
b
Interaction p-value (SNP*admixture); Bonferroni–Holm p-value for multiple comparisons shown in parenthesis; bold text indicates significance after multiple comparisons. Wald p-value within strata adjusted for multiple comparisons by NA ancestry strata (Bonferroni–Holm step-down method), bold text indicates significance (p ≤ 0.05) after multiple comparisons