Table 5.
The association of TGF-P signaling pathway genes and breast cancer risk as defined by ER/PR Phenotypes
| Gene (SNP) | Genotype | Controlsa | ER+/PR+ |
ER+/PR− |
ER−/PR+ |
ER−/PR− |
pc | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | N | ORb | (95 % CI) | N | ORb | (95 % CI) | N | ORb | (95 % CI) | N | ORb | (95 % CI) | |||
| RUNX1 (rs7279123) | CC | 1,935 | 730 | 1.00 | 160 | 1.00 | 31 | 1.00 | 249 | 1.00 | 0.01 (0.06) | ||||
| CT | 1,083 | 466 | 1.12 | (0.97, 1.29) | 65 | 0.72 | (0.53, 0.97) | 14 | 0.83 | (0.44, 1.57) | 135 | 0.98 | (0.78, 1.22) | ||
| TT | 184 | 79 | 1.10 | (0.83, 1.46) | 7 | 0.44 | (0.21, 0.96) | 0 | 0.00 | (0.00, 0.00) | 20 | 0.88 | (0.55, 1.43) | ||
| RUNX2 (rs9463090) | GG | 2,051 | 818 | 1.00 | 155 | 1.00 | 25 | 1.00 | 238 | 1.00 | 0.01 (0.09) | ||||
| GA | 1,016 | 410 | 1.02 | (0.88, 1.17) | 70 | 0.93 | (0.70, 1.25) | 17 | 1.34 | (0.72, 2.50) | 130 | 1.10 | (0.87, 1.38) | ||
| AA | 144 | 49 | 0.83 | (0.59, 1.16) | 8 | 0.72 | (0.35, 1.50) | 3 | 1.81 | (0.54, 6.10) | 38 | 2.31 | (1.57, 3.39) | ||
| RUNX2 (rs12333172) | CC/CT | 3,109 | 1238 | 1.00 | 222 | 1.00 | 43 | 1.00 | 378 | 1.00 | 0.01 (0.10) | ||||
| TT | 106 | 40 | 0.92 | (0.63, 1.33) | 11 | 1.44 | (0.76, | 2 | 1.36 | (0.32, 5.72) | 28 | 2.12 | (1.37, 3.27) | ||
| RUNX3 (rs2236850) | TT | 1,073 | 401 | 1.00 | 77 | 1.00 | 2.73) | 11 | 1.00 | 105 | 1.00 | 0.03 (0.17) | |||
| TC | 1,526 | 620 | 1.08 | (0.93, 1.26) | 112 | 1.02 | (0.76, 1.38) | 15 | 0.96 | (0.44, 2.10) | 216 | 1.44 | (1.13, 1.85) | ||
| CC | 609 | 257 | 1.12 | (0.93, 1.35) | 44 | 1.00 | (0.68, 1.46) | 18 | 2.88 | (1.35, 6.16) | 83 | 1.39 | (1.02, 1.88) | ||
| RUNX3 (rs7517302) | TT | 2,664 | 1035 | 1.00 | 191 | 1.00 | 32 | 1.00 | 324 | 1.00 | 0.005 (0.03) | ||||
| TC/CC | 548 | 242 | 1.13 | (0.96, 1.34) | 41 | 1.05 | (0.74, 1.50) | 13 | 2.02 | (1.05, 3.88) | 82 | 1.25 | (0.96) 1.62) | ||
a
ER/PR data were compared with 3,214 controls from sites where cases have ER/PR data Mexico data is excluded because they do not have data for ER/PR status (n = 1,810)
b
Odds ratios (OR) and 95 % confidence intervals (CI) adjusted for age, study, and genetic admixture; Bonferroni-Holms p-value adjustment for multiple comparisons shown in parentheses
c
Wald-p for overall model, Bonferroni-Holm p-value adjustment for MC shown in parentheses. Wald p-value within strata adjusted for multiple comparisons by admixture strata (Bonferroni-Holm step-down method), bold text indicates significance (p ≤ 0.05) after multiple comparisons