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. 2014 May 26;35(7):869–878. doi: 10.1038/aps.2014.29

Figure 4.

Figure 4

dl-PHPB reversed the LTP impairment in APP/PS1 Tg mice in vivo. (A) Typical PS waveforms recorded from different treatments. (B) LTP was decreased in APP/PS1 mice compared with non-Tg mice, but this reduction was ameliorated by dl-PHPB treatment (100 mg·kg−1·d−1 for 1 month, po). Data are expressed as the mean percentage change in PS. Analysis of the mean percentage changes in PS at 60 min after HFS. This result revealed a significant decrease in the LTP level in the APP/PS1 control group compared with non-Tg mice (cP<0.01 vs WT control group, n=5); dl-PHBP treatment significantly attenuated the LTP reduction. eP<0.05 vs Tg control group, n=5.