. 2014 Jun 9;35(7):967–979. doi: 10.1038/aps.2014.34

Table 5. Compounds selected and purchased for biological validation: inhibition of MCF-7 cell growth at 100 μmol/L concentration and IC₅₀ of selected compounds.

Compounds	SPECS/No	Structure	% Inhibition (MCF-7)	IC₅₀±SDa (μmol/L)
Compounds	SPECS/No	Structure	% Inhibition (MCF-7)	MCF-7	HBL100
1	AE-562/40322474		85±3.30	28.5±4.38	>100
2	AQ-358/42003065		69±4.14	NDb	ND
3	AQ-358/41842921		81±4.86	54±5.17	30.7±3.2
4	AE-848/10302031		53±4.27	ND	ND
5	AQ-358/42003072		65±4.35	ND	ND
Colchicine			90±3.0	4.5±6	>100

^a Concentration of compound that inhibits 50% human tumor cell growth, presented as mean±standard deviation (SD), performed at least in triplicate.

^b ND indicates not determined.

Table 5. Compounds selected and purchased for biological validation: inhibition of MCF-7 cell growth at 100 μmol/L concentration and IC50 of selected compounds.