Table 3. The Percentage of protection of 1 μmol/L compound against 80 μmol/L MPP+-induced intracellular ATP loss in the differentiated LUHMES cells. MPP+ alone group was normalized as 0% and vehicle group was normalized as 100%. Data were presented as mean±SD (n=5/group).
| Compound | Vender | Protection % (at 1 μmol/L) (mean±SD, n=5/group) |
|---|---|---|
| SCH442416 | Sigma | −1.19±0.02 |
| PJ34 | Sigma | −0.08±0.89 |
| Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone | EMD4Biosciences | 0.68±2.78 |
| SB216763 | Sigma | 104.63±13.37 |
| AR-A014418 | Sigma | −1.14±0.03 |
| Simvastatin | Sigma | 2.03±9.37 |
| Selegiline/deprenyl | Sigma | −0.43±1.61 |
| Roscovitine | Sigma | −5.17±0.55 |
| GW7647 | Sigma | −6.16±0.00 |
| Fenofibrate | sigma | −2.79±2.83 |
| Pioglitazone | Sigma | −31.50±0.14 |
| 5-Aminoimidazole-4-carboxamide ribonucleotide | Sigma | −30.84±0.26 |
| Isradipine | sigma | −31.00±0.20 |
| Nimodipine | Sigma | −29.88±1.73 |
| (R)-(+)-WIN 55212-2 mesylate salt | Sigma | −28.86±4.68 |
| AS-252424 | Sigma | 22.15±2.09 |
| Ellagic acid | Sigma | 38.13±3.14 |
| PF-3845 | Cayman chemical | −13.74±8.08 |
| N-nonyl-deoxynojirimycin | Sigma | 34.12±4.81 |
| N-Dodecyl-1-deoxynojirimycin | Sigma | 58.35±0.61 |
| PD166793 | Sigma | 44.35±34.49 |
| CP-471474 | Sigma | 54.89±21.17 |
| RS 504393 | TocRis bioscience | −126.37±25.79 |
| Bay 11-7085 | Sigma | −146.49±0.56 |
| Celastrol | Sigma | −133.68±1.20 |
| Desipramine | Sigma | 7.73±3.89 |
| Flupirtine maleate salt | Sigma | −0.17±4.72 |
| Imipramine hydrochloride | Sigma | 17.51±8.40 |
| Eicosapentaenoic acid | Enzo | −21.28±19.79 |
| Valproic acid sodium salt | Enzo | 41.12±18.61 |
| SU4312 | Enzo | 7.36±3.70 |
| Coenzyme Q10 | Sigma | 5.34±4.27 |
| alpha-Lipoic acid | Sigma | 10.34±7.03 |
| O-Acetyl-L-carnitine hydrochloride | Sigma | 19.62±5.16 |
| GW8510 | Sigma | 154.26±14.84 |