Table 1.
MDMA-related mean (SEM) heart rate, blood pressure, and self-report ratings over the entire session, calculated as change from pre-capsule.
| Drug Condition | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Placebo | 0.75 mg/kg MDMA |
1.5 mg/kg MDMA |
Main Effect of Dose | ||||||
| Mean | (SEM) | Mean | (SEM) | Mean | (SEM) | F (2,26) | p | χ2 | |
| Cardiovascular measures | |||||||||
| Heart Rate | 1.7 | (0.7) | 8.7 | (1.7) * | 16.0 | (2.9) *§ | 17.5 | <0.001 | 0.26 |
| Systolic Pressure | 1.2 | (2.5) | 14.5 | (1.9) * | 27.1 | (2.2) *§ | 35.2 | <0.001 | 0.36 |
| Diastolic Pressure | 0.4 | (1.2) | 6.7 | (1.2) * | 11.5 | (1.2) * | 23.8 | <0.001 | 0.27 |
| Drug Effects Questionnaire | |||||||||
| Feel Drug | 6.4 | (2.3) | 24.4 | (4.7) * | 44.4 | (3.9) *§ | 47.7 | <0.001 | 0.27 |
| Feel High | 5.4 | (2.3) | 20.6 | (4.8) * | 43.7 | (3.2) *§ | 59.7 | <0.001 | 0.28 |
| Like Drug | 5.0 | (3.0) | 22.4 | (4.7) * | 47.8 | (4.0) *§ | 39.6 | <0.001 | 0.30 |
| Dislike Drug | 7.9 | (2.9) | 12.8 | (2.9) | 15.3 | (5.5) | 4.7 | 0.018 | 0.06 |
| Want More | 6.4 | (3.1) | 22.5 | (6.1) * | 41.5 | (6.2) *§ | 20.0 | <0.001 | 0.24 |
| Visual Analog Scales | |||||||||
| Anxious | 2.2 | (4.0) | 11.5 | (4.3) | 14.2 | (4.0) | 2.3 | 0.124 | 0.04 |
| Confident | −3.9 | (1.9) | 1.3 | (2.4) | 10.1 | (4.9) | 5.2 | 0.013 | 0.17 |
| Dizzy | 5.3 | (3.2) | 6.4 | (5.4) | 15.4 | (6.4) | 5.9 | 0.008 | 0.06 |
| Elated | 2.6 | (1.6) | 16.0 | (4.4) * | 33.3 | (5.4) *§ | 23.3 | <0.001 | 0.25 |
| Friendly | −3.2 | (2.5) | 5.0 | (3.0) | 17.8 | (4.3) * | 13.6 | <0.001 | 0.24 |
| Insightful | 0.7 | (1.7) | 10.5 | (4.8) | 23.7 | (5.4) * | 18.6 | <0.001 | 0.26 |
| Lonely | −0.1 | (1.8) | 4.8 | (3.7) | 11.1 | (5.5) | 1.1 | 0.363 | 0.03 |
| Loving | 0.3 | (1.6) | 4.7 | (2.8) | 28.6 | (5.8) *§ | 18.2 | <0.001 | 0.26 |
| Playful | −4.5 | (2.5) | 5.4 | (2.9) | 15.7 | (5.6) | 4.5 | 0.021 | 0.12 |
| Restless | 7.2 | (3.0) | 18.1 | (4.2) | 27.3 | (5.5) * | 10.2 | 0.001 | 0.13 |
| Sedated | 1.8 | (3.7) | 0.6 | (2.6) | 5.0 | (2.8) | 0.8 | 0.464 | 0.01 |
| Sociable | −3.6 | (2.2) | 4.5 | (3.8) | 11.8 | (5.2) * | 7.9 | 0.002 | 0.18 |
| Stimulated | 4.2 | (2.0) | 19.2 | (4.5) | 36.3 | (5.3) * | 40.4 | <0.001 | 0.28 |
*
significantly different from placebo
§
significantly different from 0.75 mg/kg