Table 1.
Characteristics of MESA Lung Study Participants at Baseline Stratified by Quintiles of Plasma Sphingomyelin Level.
| Quintiles of Sphingomyelin, (range in mg/dL) | |||||
|---|---|---|---|---|---|
| 1st Quintile (19 – 35) |
2nd Quintile (36 – 42) |
3rd Quintile (43 – 49) |
4th Quintile (50 – 59) |
5th Quintile (60 – 125) |
|
|
|
|||||
| n= 799 | n= 778 | n= 746 | n= 773 | n= 744 | |
| Age, mean (SD), years | 61 (10) | 60 (10) | 61 (10) | 62 (10) | 63 (10) |
| Male gender, (%) | 62% | 55% | 48% | 46% | 36% |
| Race/ethnicity, (%) | |||||
| - White (Non-Hispanic) | 43% | 38% | 36% | 33% | 29% |
| - Chinese-American | 15% | 18% | 17% | 17% | 14% |
| - Black (Non-Hispanic) | 22% | 23% | 26% | 27% | 31% |
| - Hispanic | 20% | 22% | 21% | 24% | 26% |
| Education, years, (%) | |||||
| - <High school | 14% | 17% | 15% | 18% | 20% |
| - High school graduate | 18% | 17% | 17% | 20% | 20% |
| - Some college | 28% | 27% | 28% | 27% | 28% |
| - College graduate | 20% | 18% | 18% | 18% | 17% |
| - >Bachelor’s degree | 20% | 21% | 22% | 17% | 15% |
| Height, mean (SD), cm | 169 (9) | 168 (10) | 167 (10) | 166 (10) | 164 (10) |
| Weight, mean (SD), Kg | 79 (16) | 78 (18) | 78 (17) | 78 (17) | 77 (18) |
| Body mass index, mean (SD), kg/m2 | 27.8 (4.9) | 27.9 (5.4) | 28.0 (5.1) | 28.3 (5.4) | 28.4 (5.5) |
| Cigarette smoking,(%) | |||||
| - Never | 40% | 48% | 50% | 51% | 50% |
| - Past | 44% | 38% | 37% | 37% | 38% |
| - Current | 16% | 14% | 13% | 12% | 12% |
|
Cigarettes smoked /day, median (IQR) * |
10 (5, 20) 22902 |
15 (6, 20) 23282 |
10 (3, 18) 22294 |
10 (5, 15) 16711 |
10 (5, 20) 24907 |
| Cotinine, median (IQR), nmol/L * | (7855, 46678) |
(9025, 40197) |
(7407, 37744) |
(5578, 37107) |
(7793, 45997) |
| Pack-years, median (IQR) † | 14 (3, 35) | 16 (4, 34) | 17 (4, 32) | 14 (2, 30) | 17 (6, 34) |
|
Total cholesterol, mean (SD),
mmol/L |
4.79 (0.80) | 4.90 (0.88) | 4.97 (0.83) | 5.05 (0.91) | 5.39 (0.96) |
| Triglycerides, mean (SD), mmol/L | 1.22 (0.52) | 1.31 (0.61) | 1.47 (0.71) | 1.50 (0.87) | 1.85 (1.27) |
| LDL, mean (SD), mmol/L | 2.95 (0.73) | 2.98 (0.80) | 3.00 (0.78) | 3.03 (0.80) | 3.24 (0.83) |
| HDL, mean (SD), mmol/L | 1.30 (0.34) | 1.30 (0.36) | 1.30 (0.36) | 1.32 (0.39) | 1.37 (0.44) |
|
Systolic Blood Pressure, mean (SD),
mmHg |
125 (19) | 123 (19) | 125 (20) | 125 (20) | 126 (21) |
|
Diastolic Blood Pressure, mean (SD),
mmHg |
73 (10) | 72 (10) | 72 (10) | 71 (10) | 71 (10) |
| Family history of emphysema, (%) | 5% | 4% | 5% | 3% | 4% |
| Airflow Limitation, (%) ‡ | 14% | 11% | 10% | 13% | 10% |
| CT scanners at Baseline | |||||
| - Siemens S4+ Volume Zoom | 239 (30%) | 199 (26%) | 172 (23%) | 206 (27%) | 184 (25%) |
| - Imatron C-150 | 426 (53%) | 778 (59%) | 462 (62%) | 459 (59%) | 460 (62%) |
| - GE Light Speed QX/I | 27 (4%) | 21 (3%) | 18 (2%) | 13 (2%) | 12 (2%) |
| - GE Light Speed Plus | 107 (13%) | 98 (13%) | 94 (13%) | 95 (12%) | 88 (12%) |
| CT scanners at Last Follow-Up | |||||
| - Siemens S4+ Volume Zoom | 96 (13%) | 69 (9%) | 56 (8%) | 63 (8%) | 46 (6%) |
| - Siemens Sensation 16 | 72 (9%) | 77 (10%) | 68 (9%) | 83 (11%) | 74 (10%) |
| - Siemens Sensation 64 | 43 (6%) | 57 (8%) | 75 (10%) | 79 (11%) | 104 (15%) |
| - Imatron C-150 | 368 (48%) | 383 (51%) | 369 (51%) | 359 (48%) | 336 (47%) |
| - GE Light Speed Plus | 8 (1%) | 5 (1%) | 3 (0%) | 13 (2%) | 6 (1%) |
| - GE Light Speed Pro 16 | 123 (16%) | 111 (15%) | 107 (15%) | 94 (13%) | 92 (13%) |
| - Toshiba Aquilion 32 | 3 (0%) | 5 (1%) | 3 (0%) | 9 (1%) | 7 (1%) |
| - Toshiba Aquilion 64 | 52 (7%) | 45 (6%) | 38 (5%) | 44 (6%) | 52 (7%) |
*
Among current smokers at baseline exam.
†
Pack-years among ever smokers at baseline exam.
‡
Defined by FEV1/FVC ratio < lower limit of normal.