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Characterization of OPTanti-ATF6 and OPTanti-FOS. (A) Specificity profiles of the designed peptides targeting ATF6 and FOS at 37°C plotted as in Figure 2. All Kd values are listed in Supporting Information Tables I and VIII. (B) Anti-FOS and redesigned OPTanti-FOS acting as inhibitors of the interaction between 10 nM FOS and 10 nM JUN in the presence of 40 nM DNA at 37°C. The average IC50 values fit for anti-FOS and OPTanti-FOS were 38 and 16 nM, respectively.
